LOC108348112 Gene Summary [Rat]
Predicted to enable several functions, including chromatin binding activity; lysine-acetylated histone binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including chromatin looping; nucleosome assembly; and positive regulation of T-helper 17 cell lineage commitment. Predicted to act upstream of or within neural tube closure. Predicted to be located in cytoplasm and nuclear speck. Predicted to be active in chromatin and nucleus. Human ortholog(s) of this gene implicated in B-cell lymphoma; B-lymphoblastic leukemia/lymphoma; juvenile myoclonic epilepsy; and photosensitivity disease. Orthologous to human BRD2 (bromodomain containing 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | LOC108348112 |
| Official Name | bromodomain-containing protein 2 [Source:RGD Symbol;Acc:11509343] |
| Ensembl ID | ENSRNOG00000000461 |
| Bio databases IDs | |
| Aliases | bromodomain-containing protein 2 |
| Synonyms | BRD2-IT1, bromodomain containing 2, D17H6S113E, D6S113E, Frg-1, FSH, FSHRG1, FSRG1, LOC100043003, LOC105375109, LOC108348112, mKIAA4005, NAT, O27.1.1, RING3, RNF3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Loc108348112 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- protein serine/threonine kinase
- histone binding
- degron
- protein binding activity, bridging
- chromatin binding
- protein binding
- extraterminal domain
- Bromodomain extra-terminal - transcription regulation
- Bromodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- Crohn disease
- lymphomagenesis
- acute tonsillitis
- inflammatory bowel disease
- ulcerative colitis
- tuberculosis
- pulmonary hypertensive arterial disease
- sarcoidosis
role in cell
- binding in
- expression in
- activation in
- production in
- transcription in
- growth
- assembly
- differentiation
- survival
- damage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- nucleoplasm
- nuclear speckles
- chromatin
- euchromatin compartments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Loc108348112 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neural tube closure
- protein localization to chromatin
- spermatogenesis
- positive regulation of T-helper 17 cell lineage commitment
- nucleosome assembly
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone acetyl-lysine binding
- chromatin binding
- protein serine/threonine kinase activity