Nutf2 Gene Summary [Rat]
Enables nuclear import signal receptor activity and small GTPase binding activity. Involved in negative regulation of vascular endothelial growth factor production; positive regulation of protein import into nucleus; and protein localization to nucleus. Located in cytosol and nuclear outer membrane. Part of nuclear pore central transport channel. Used to study diabetic retinopathy. Orthologous to human NUTF2 (nuclear transport factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nutf2 |
| Official Name | nuclear transport factor 2 [Source:RGD Symbol;Acc:1359213] |
| Ensembl ID | ENSRNOG00000018945 |
| Bio databases IDs | |
| Aliases | nuclear transport factor 2 |
| Synonyms | 2700067I02Rik, NTF-2, Ntf3, nuclear transport factor 2, PP15 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nutf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of nuclear pore
- enzyme binding
- protein binding
- NTF2_like
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Hutchinson-Gilford progeria syndrome
- Waldenström macroglobulinemia
role in cell
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- outer nuclear membrane
- nuclear envelope
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nutf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein localization to nuclear pore
- protein import into nucleus
- protein export from nucleus
- mRNA transport
Cellular Component
Where in the cell the gene product is active
- nuclear inner membrane
- nuclear membrane
- extracellular vesicular exosome
- cytosol
- nuclear outer membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- structural constituent of nuclear pore
- small GTPase binding