Retn Gene Summary [Rat]
Predicted to enable hormone activity. Involved in several processes, including negative regulation of feeding behavior; positive regulation of cell communication; and response to insulin. Located in extracellular space. Used to study colitis. Biomarker of metabolic dysfunction-associated steatotic liver disease. Human ortholog(s) of this gene implicated in hypertension; hypertrophic cardiomyopathy; obesity; and type 2 diabetes mellitus. Orthologous to human RETN (resistin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Retn |
| Official Name | resistin [Source:RGD Symbol;Acc:628781] |
| Ensembl ID | ENSRNOG00000001001 |
| Bio databases IDs | |
| Aliases | resistin |
| Synonyms | ADSF, FIZZ3, HXCP1, RENT, RESISTIN, RETN1, RSTN, XCP1, Xcp4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Retn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- resistin-like molecule (RELM) hormone family
- hormone
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- fibrosis
- impaired glucose tolerance
- chronic kidney disease
- insulin resistance
- abdominal aortic aneurysm
- non-insulin-dependent diabetes mellitus
- cardiotoxicity
- septic shock
- acute lung injury
- arthritis
role in cell
- expression in
- apoptosis
- activation
- formation
- activation in
- proliferation
- phosphorylation in
- cellular infiltration by
- differentiation
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- secretory granule lumen
- azurophil granule lumen
- Cytoplasm
- vesicles
- Endoplasmic Reticulum
- azurophil granules
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Retn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to insulin stimulus
- negative regulation of feeding behavior
- signal transduction
- positive regulation of synaptic transmission
- fat cell differentiation
- response to mechanical stimulus
- positive regulation of progesterone secretion
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- specific granule lumen
- extracellular region
- azurophil granule lumen
Molecular Function
What the gene product does at the molecular level
- protein binding
- hormone activity