Trpc1 Gene Summary [Rat]
Predicted to enable several functions, including ATPase binding activity; inositol 1,4,5 trisphosphate binding activity; and store-operated calcium channel activity. Involved in cellular response to hypoxia and modulation of chemical synaptic transmission. Is active in postsynaptic membrane and presynaptic membrane. Biomarker of type 2 diabetes mellitus. Orthologous to human TRPC1 (transient receptor potential cation channel subfamily C member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trpc1 |
| Official Name | transient receptor potential cation channel, subfamily C, member 1 [Source:RGD Symbol;Acc:619783] |
| Ensembl ID | ENSRNOG00000054902 |
| Bio databases IDs | |
| Aliases | transient receptor potential cation channel, subfamily C, member 1 |
| Synonyms | HTRP-1, LOC100909709, Mtrp1, transient receptor potential cation channel subfamily C member 1, transient receptor potential cation channel, subfamily C, member 1, Transient receptor protein 1, TRP1, TRRP1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Trpc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ion transport protein
- calcium channel
- Ankyrin repeats (3 copies)
- store-operated calcium channel
- protein binding
- receptor binding
- proline rich domain
- ion channel
- ATPase binding
- binding protein
- transmembrane domain
- Transient receptor ion channel II
- ion channel binding
- transient-receptor-potential calcium channel protein
- Transient Receptor Potential channel, Vanilloid subfamily (TRPV)
- cation channel
Pathways
Biological processes and signaling networks where the Trpc1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight gain
- hyperalgesia
- heart failure
- polyarteritis nodosa
- mechanical hyperalgesia
- Hutchinson-Gilford progeria syndrome
- hypoxia-induced pulmonary hypertension
- insulin-induced hypoglycemia
role in cell
- phosphorylation in
- growth
- binding in
- expression in
- apoptosis
- number
- migration
- proliferation
- cell death
- endoplasmic reticulum stress response in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- nuclear membrane fraction
- Cytoplasm
- cell surface
- cell periphery
- intracellular membranes
- cellular membrane
- costameres
- sarcomere
- cytosol
- microsome
- presynaptic membrane
- postsynaptic membrane
- basolateral membrane
- Golgi stacks
- synaptosomes
- sarcolemma
- melanosomes
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Trpc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- melanin biosynthetic process
- response to calcium ion
- calcium ion transport
- cytosolic calcium ion homeostasis
- calcium ion transmembrane transport
- positive regulation of release of sequestered calcium ion into cytosol
Cellular Component
Where in the cell the gene product is active
- receptor complex
- cation channel complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- store-operated calcium channel activity
- protein binding
- calcium channel activity
- cation channel activity
- receptor binding
- ATPase binding
- inositol 1,4,5 trisphosphate binding