Arnt Gene Summary [Rat]
Contributes to sequence-specific DNA binding activity. Involved in several processes, including G1 to G0 transition; nitric oxide metabolic process; and response to dexamethasone. Predicted to be located in cytoplasm and nuclear body. Predicted to be part of RNA polymerase II transcription regulator complex and nuclear aryl hydrocarbon receptor complex. Predicted to be active in nucleus. Biomarker of hypertension. Human ortholog(s) of this gene implicated in renal cell carcinoma. Orthologous to human ARNT (aryl hydrocarbon receptor nuclear translocator). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arnt |
| Official Name | aryl hydrocarbon receptor nuclear translocator [Source:RGD Symbol;Acc:2153] |
| Ensembl ID | ENSRNOG00000031174 |
| Bio databases IDs | |
| Aliases | aryl hydrocarbon receptor nuclear translocator |
| Synonyms | ARNT1, aryl hydrocarbon receptor nuclear translocator, bHLHe2, D3Ertd557e, DIOXIN receptor, Drnt, ESTM42, HIF1B, HIF1BETA, HIF-1-β, HIF beta, HIF β, mKIAA4051, TANGO |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Arnt often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription activation domain
- transcription factor binding
- AF-2 transcription activation domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- PAS B-subdomain
- aryl hydrocarbon receptor binding
- ligand-dependent nuclear receptor
- helix-loop-helix domain
- PAS A-subdomain
- Helix-loop-helix DNA-binding domain
- basic domain
- D-Box
- DNA binding domain
- nucleic acid binding
- PAS
- basic Helix Loop Helix (bHLH) domain superfamily
- alpha helix
- protein binding
- basic helix loop helix/Per Arnt Sim domain
- sequence-specific DNA binding
- PAS fold
- binding protein
- PAS domain
- double-stranded DNA binding
- protein homodimerization
- helix loop helix domain
- Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)
- transcription factor activity
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Arnt gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Adrenomedullin signaling pathway
- Apelin Cardiomyocyte Signaling Pathway
- Apelin Endothelial Signaling Pathway
- Aryl Hydrocarbon Receptor Signaling
- Autophagy
- Erythropoietin Signaling
- HIF1α Signaling
- Hypoxia Signaling in the Cardiovascular System
- Iron homeostasis signaling pathway
- Renal Cell Carcinoma Signaling
- VEGF Signaling
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cutaneous melanoma
- obesity
- immune thrombocytopenia
- non-insulin-dependent diabetes mellitus
- fibrosis
- organismal death
- growth failure
- hypoplasia
- cutaneous melanoma cancer
- meningioma
role in cell
- apoptosis
- proliferation
- migration
- expression in
- growth
- production in
- adhesion
- maturation
- quantity
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- nucleoplasm
- nuclear bodies
- chromatin
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Arnt gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of inflammatory response
- positive regulation of hormone biosynthetic process
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of erythrocyte differentiation
- embryonic placenta development
- regulation of transcription from RNA polymerase II promoter
- response to hypoxia
- positive regulation of vascular endothelial growth factor receptor signaling pathway
- cell differentiation
- cellular response to oxidative stress
- positive regulation of protein sumoylation
- positive regulation of endothelial cell proliferation
- positive regulation vascular endothelial growth factor production
- intracellular receptor mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- cytoplasm
- nuclear aryl hydrocarbon receptor complex
- aryl hydrocarbon receptor complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- protein homodimerization activity
- aryl hydrocarbon receptor binding
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
- protein heterodimerization activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity