Ppp1r2 Gene Summary [Rat]
Enables protein domain specific binding activity. Predicted to be involved in intracellular signal transduction. Located in dendritic spine and growth cone. Orthologous to several human genes including PPP1R2 (protein phosphatase 1 regulatory inhibitor subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppp1r2 |
| Official Name | protein phosphatase 1, regulatory (inhibitor) subunit 2 [Source:RGD Symbol;Acc:621099] |
| Ensembl ID | ENSRNOG00000001733 |
| Bio databases IDs | |
| Aliases | protein phosphatase 1, regulatory (inhibitor) subunit 2 |
| Synonyms | 0610025N14Rik, 2310007G06Rik, 4930440J04Rik, 5430408E15Rik, D16Ertd248e, I-2, INH-2, IPP-2, Phosphatase Inhibitor-2, PPP1R2A, protein PHOSPHATASE 1 REGULATORY INHIBITOR subunit 2, protein phosphatase 1, regulatory (inhibitor) subunit 2, protein phosphatase 1, regulatory inhibitor subunit 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ppp1r2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- type 1 serine/threonine specific protein phosphatase inhibitor
- phosphoprotein phosphatase
- phosphatase
- Protein phosphatase inhibitor 2 (IPP-2)
- PP1 binding domain
- protein domain specific binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- androgenic alopecia
- Waldenström macroglobulinemia
- renal cell carcinoma
- renal cell cancer
regulated by
- SB 216763
- GSK3
- PP1
- STK11
- CK2
- microcystin-LR
- heavy metal
- Org 2058
- PP2A
- PP1C
role in cell
- apoptosis
- meiosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- dendritic spines
- growth cone
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ppp1r2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- generation of precursor metabolites and energy
- glycogen metabolic process
- regulation of phosphoprotein phosphatase activity
- regulation of signal transduction
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase inhibitor activity
- protein phosphatase inhibitor activity
- protein binding