Tbxa2r Gene Summary [Rat]
Enables thromboxane receptor activity. Involved in several processes, including cellular response to lipopolysaccharide; positive regulation of vasoconstriction; and response to testosterone. Located in acrosomal vesicle. Used to study adult respiratory distress syndrome; kidney failure; thrombocytopenia; and toxic shock syndrome. Human ortholog(s) of this gene implicated in aspirin-induced respiratory disease; asthma; and blood platelet disease. Orthologous to human TBXA2R (thromboxane A2 receptor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tbxa2r |
| Official Name | thromboxane A2 receptor [Source:RGD Symbol;Acc:3825] |
| Ensembl ID | ENSRNOG00000020585 |
| Bio databases IDs | |
| Aliases | thromboxane A2 receptor |
| Synonyms | BDPLT13, TBXA2, thromboxane A2 receptor, Thromboxane prostanoid receptor, TP, TP-R, TXA2/PGH2 receptor, TXA2-R, TXA2 receptor, Txr |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tbxa2r often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- ERY motif
- thromboxane A2 receptor
- cytoplasmic domain
- thromboxane receptor
- guanyl-nucleotide exchange factor
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- cytosolic tail domain
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Tbxa2r gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- edema
- liver disease
- kidney disease
- heart failure
- essential hypertension
- hypersensitivity reaction type I
- tachycardia
- qualitative platelet disorder
- organismal death
regulated by
- curcumin
- I-BOP
- 15-deoxy-delta-12,14 -PGJ 2
- U46619
- dinoprost
- Collagen(s)
- dexamethasone
- tetradecanoylphorbol acetate
- PKC
- HGF
role in cell
- phosphorylation in
- expression in
- apoptosis
- proliferation
- activation in
- G2/M phase
- activation
- migration
- response
- generation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- membrane fraction
- cell surface
- cellular membrane
- Endoplasmic Reticulum
- demarcation membrane systems
- basolateral membrane
- nuclear speckles
- alpha granules
- acrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tbxa2r gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of blood coagulation
- G-protein coupled receptor signaling pathway
- positive regulation of vasoconstriction
- response to nutrient
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- response to xenobiotic stimulus
- negative regulation of cell migration involved in sprouting angiogenesis
- positive regulation of angiogenesis
- positive regulation of blood pressure
- elevation of cytosolic calcium ion concentration
- positive regulation of smooth muscle contraction
- response to ethanol
- inflammatory response
- cellular response to lipopolysaccharide
- smooth muscle contraction
- response to testosterone stimulus
Cellular Component
Where in the cell the gene product is active
- nuclear speck
- acrosomal vesicle
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity
- thromboxane A2 receptor activity