Tnk2 Gene Summary [Rat]
Enables protein tyrosine kinase activity. Predicted to be involved in several processes, including positive regulation of peptidyl-tyrosine phosphorylation; regulation of clathrin-dependent endocytosis; and spermatid development. Predicted to be located in several cellular components, including clathrin-coated pit; cytoophidium; and cytoplasmic vesicle. Predicted to be part of Grb2-EGFR complex. Predicted to be active in plasma membrane; postsynaptic cytosol; and presynaptic cytosol. Orthologous to human TNK2 (tyrosine kinase non receptor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tnk2 |
| Official Name | tyrosine kinase, non-receptor, 2 [Source:RGD Symbol;Acc:1305957] |
| Ensembl ID | ENSRNOG00000001769 |
| Bio databases IDs | |
| Aliases | tyrosine kinase, non-receptor, 2 |
| Synonyms | ACK, ACK1, Cdgip, LOC682784, p21cdc42Hs, Pyk1, tyrosine kinase non receptor 2, tyrosine kinase, non-receptor, 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tnk2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- p21 binding domain
- protein threonine/tyrosine kinase
- SAM domain
- protein-tyrosine kinase
- Protein kinase domain
- EGFR receptor inhibitor Mig-6
- identical protein binding
- proline rich domain
- GTPase inhibitor
- Tyrosine kinase, catalytic domain
- UBA domain-like superfamily
- ubiquitin protein ligase binding
- Protein kinase (unclassified specificity)
- GTPase binding
- PPXY motif
- Protein tyrosine and serine/threonine kinase
- epidermal growth factor receptor binding
- SAM (Sterile alpha motif )
- clathrin box motif
- WW domain binding
- non-membrane spanning protein tyrosine kinase
- protein binding
- Src Homology 3 domain superfamily
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- Cdc42 binding domain
Pathways
Biological processes and signaling networks where the Tnk2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- CD30 positive anaplastic large cell lymphoma
- ovarian cancer
- cervical adenosquamous carcinoma
- advanced lung squamous cell carcinoma
- metastatic large cell lung carcinoma
- locally advanced non-small cell lung cancer
- stage IV lung squamous cell carcinoma
- advanced non-small cell lung cancer
- high-grade diffuse glioma
role in cell
- cell death
- expression in
- phosphorylation in
- binding in
- cell viability
- growth
- activation in
- number
- invasion
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- intracellular membrane-bounded organelle
- Nucleus
- Plasma Membrane
- endosomes
- vesicles
- cytosol
- growth cone
- clathrin-coated pits
- perikaryon
- axons
- dendrites
- clathrin-coated vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tnk2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- small GTPase mediated signal transduction
- cell surface receptor signaling pathway
- phosphorylation
- endocytosis
- protein phosphorylation
- regulation of clathrin-mediated endocytosis
- positive regulation of peptidyl-tyrosine phosphorylation
Cellular Component
Where in the cell the gene product is active
- plasma membrane
- nucleus
- adherens junction
- cytoplasmic vesicle membrane
- perinuclear region of cytoplasm
- endosome
- cytoplasm
- cytoophidium
- intracellular membrane-bounded organelle
- coated pit
- membrane
- cytosol
- clathrin-coated vesicle
- Grb2-EGFR complex
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- GTPase inhibitor activity
- epidermal growth factor receptor binding
- protein serine/threonine kinase activity
- ATP binding
- protein tyrosine kinase activity
- protein binding
- ubiquitin protein ligase binding
- protein serine/threonine/tyrosine kinase activity
- non-membrane spanning protein tyrosine kinase activity
- metal ion binding
- WW domain binding