Snx9 Gene Summary [Rat]
Predicted to enable several functions, including 1-phosphatidylinositol binding activity; Arp2/3 complex binding activity; and protein homodimerization activity. Involved in regulation of synaptic vesicle endocytosis. Is active in presynapse. Orthologous to human SNX9 (sorting nexin 9). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Snx9 |
| Official Name | sorting nexin 9 [Source:RGD Symbol;Acc:1584466] |
| Ensembl ID | ENSRNOG00000046874 |
| Bio databases IDs | |
| Aliases | sorting nexin 9 |
| Synonyms | 2700073N08Rik, LOC100039155, SDP1, SH3PX1, SH3PXD3A, sorting nexin 9, WISP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Snx9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- phosphoinositide binding domain
- alpha helix
- protein binding
- Bin/Amphiphysin/Rvs domain
- identical protein binding
- phosphatidylinositol binding
- Src Homology 3 domain superfamily
- binding protein
- protein homodimerization
- The Phox Homology domain, a phosphoinositide binding module
- PX domain
- transporter
Pathways
Biological processes and signaling networks where the Snx9 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- Alzheimer disease
- infection
- colorectal carcinoma
- colorectal carcinomagenesis
- melanoma cancer
- collagen-induced arthritis
- brain infarction
- melanoma
- borderline personality disorder
role in cell
- replication in
- quantity
- degradation in
- formation
- remodeling
- binding
- tubulation
- internalization by
- ubiquitination in
- translocation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- cytoplasmic vesicle membrane
- presynaptic regions
- perinuclear Golgi regions
- cell surface
- perinuclear region
- Plasma Membrane
- vesicles
- Golgi Apparatus
- cytosol
- trans Golgi network
- cuticular plate
- cytoplasmic vesicles
- clathrin-coated pits
- filopodia
- clathrin-coated vesicles
- macropinosomes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Snx9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cleavage furrow formation
- macromolecular complex assembly
- regulation of synaptic vesicle endocytosis
- lipid tube assembly
- intracellular protein transport
- endocytosis
- receptor-mediated endocytosis
- positive regulation of GTPase activity
- membrane tubulation
- positive regulation of membrane protein ectodomain proteolysis
- positive regulation of protein kinase activity
- cytokinesis after mitosis
- positive regulation of actin filament polymerization
- endosomal transport
Cellular Component
Where in the cell the gene product is active
- cytoplasmic vesicle membrane
- trans-Golgi network
- extracellular vesicular exosome
- cytoplasm
- coated pit
- ruffle
- cytoplasmic vesicle
- cytosol
- clathrin-coated vesicle
- cuticular plate
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- ubiquitin protein ligase binding
- protein homodimerization activity
- cadherin binding
- phosphatidylinositol binding
- 1-phosphatidylinositol binding
- Arp2/3 complex binding