LOC100911248 Gene Summary [Rat]
Predicted to enable several functions, including identical protein binding activity; phosphotyrosine residue binding activity; and receptor tyrosine kinase binding activity. Predicted to be involved in several processes, including positive regulation of skeletal muscle acetylcholine-gated channel clustering; positive regulation of substrate adhesion-dependent cell spreading; and regulation of intracellular signal transduction. Predicted to act upstream of or within several processes, including cell surface receptor signaling pathway; circulatory system development; and nervous system development. Predicted to be located in cytosol; nucleoplasm; and synapse. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and neuromuscular junction. Predicted to be extrinsic component of postsynaptic membrane. Human ortholog(s) of this gene implicated in chronic myeloid leukemia. Orthologous to human CRKL (CRK like proto-oncogene, adaptor protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | LOC100911248 |
| Official Name | crk-like protein-like [Source:RGD Symbol;Acc:6493647] |
| Ensembl ID | ENSRNOG00000001868 |
| Bio databases IDs | |
| Aliases | crk-like protein-like |
| Synonyms | 1110025F07Rik, CRK like proto-oncogene, adaptor protein, Crkol, LOC100911248, mgc94609, snoop, v-crk avian sarcoma virus CT10 oncogene homolog-like |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Loc100911248 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- protein binding activity, bridging
- Src homology 2 (SH2) domain
- phosphotyrosine binding
- transcription factor binding
- protein binding
- identical protein binding
- Src Homology 3 domain superfamily
- phosphorylation site
Pathways
Biological processes and signaling networks where the Loc100911248 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- hypertelorism
- otic hypertelorism
- lymphomagenesis
- hematologic cancer
- lymphoid cancer
- hematological neoplasia
- lymphatic neoplasia
- double outlet right ventricle
- embryonal rhabdomyosarcoma
role in cell
- expression in
- apoptosis
- proliferation
- formation
- phosphorylation in
- cell viability
- growth
- migration
- morphology
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- focal complexes
- focal adhesions
- Nucleus
- Plasma Membrane
- cytosol
- nucleoplasm
- perinuclear space
- neuromuscular junctions
- synapse
- ruffled borders
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Loc100911248 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of Rac protein signal transduction
- helper T cell diapedesis
- male gonad development
- positive regulation of cell proliferation
- anterior/posterior pattern specification
- outflow tract morphogenesis
- fibroblast growth factor receptor signaling pathway
- JNK cascade
- single fertilization
- thymus development
- cell chemotaxis
- regulation of dendrite development
- neuron migration
- retinoic acid receptor signaling pathway
- blood vessel development
- cell migration
- intracellular signal transduction
- T cell receptor signaling pathway
- dendrite development
- reelin-mediated signaling pathway
- spermatogenesis
- Ras protein signal transduction
- hippocampus development
- positive regulation of substrate adhesion-dependent cell spreading
- enzyme linked receptor protein signaling pathway
- cerebral cortex development
- parathyroid gland development
- B cell apoptotic process
- negative regulation of gene expression
- regulation of cell adhesion mediated by integrin
- cellular response to transforming growth factor beta stimulus
- regulation of T cell migration
- urogenital system development
- regulation of cell growth
- negative regulation of protein phosphorylation
- positive regulation of protein phosphorylation
- lipid metabolic process
- positive regulation of ERK1 and ERK2 cascade
- establishment of cell polarity
- cellular response to xenobiotic stimulus
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- neuromuscular junction
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- phosphotyrosine binding
- identical protein binding
- protein binding
- RNA binding
- signaling adaptor activity
- cadherin binding
- receptor tyrosine kinase binding