Bmp3 Gene Summary [Rat]
Enables growth factor activity. Predicted to be involved in negative regulation of ossification. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Located in extracellular space and vesicle. Orthologous to human BMP3 (bone morphogenetic protein 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bmp3 |
| Official Name | bone morphogenetic protein 3 [Source:RGD Symbol;Acc:2212] |
| Ensembl ID | ENSRNOG00000002381 |
| Bio databases IDs | |
| Aliases | bone morphogenetic protein 3 |
| Synonyms | 9530029I04Rik, BMP-3A, BMPY, bone morphogenetic protein 3, D630004D15Rik, Osteogenin, PBMP3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Bmp3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TGF_beta_SF
- Transforming growth factor beta like domain
- receptor binding
- growth factor
Pathways
Biological processes and signaling networks where the Bmp3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Axonal Guidance Signaling
- Basal Cell Carcinoma Signaling
- BMP signaling pathway
- Factors Promoting Cardiogenesis in Vertebrates
- Human Embryonic Stem Cell Pluripotency
- Iron homeostasis signaling pathway
- Molecular Mechanisms of Cancer
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- degenerative disc disease
- myopia
- ulcerative colitis
- refractive error
- astigmatism
- retinal detachment
- progressive vision loss
- cataract
role in cell
- differentiation
- phosphorylation in
- expression in
- ossification by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Bmp3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- skeletal system development
- signal transduction
- cell-cell signaling
- osteoblast differentiation
- cartilage development
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- cytokine activity
- receptor binding
- BMP receptor binding