Ralb Gene Summary [Rat]
Predicted to enable GTPase activity; enzyme binding activity; and guanyl ribonucleotide binding activity. Involved in regulation of exocyst assembly and regulation of exocyst localization. Predicted to be located in midbody. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in pancreatic adenocarcinoma. Orthologous to human RALB (RAS like proto-oncogene B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ralb |
| Official Name | RAS like proto-oncogene B [Source:RGD Symbol;Acc:619852] |
| Ensembl ID | ENSRNOG00000002440 |
| Bio databases IDs | |
| Aliases | RAS like proto-oncogene B |
| Synonyms | 5730472O18Rik, dRalb, RAS like proto-oncogene B, v-ral simian leukaemia viral oncogene B, v-ral simian leukemia viral oncogene B |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ralb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- calmodulin binding domain
- GTPase
- enzyme
- geranylgeranylation site
- protein binding
- Ras subfamily of RAS small GTPases
- GTP binding
- ATPase binding
- small GTP-binding protein domain
- GDP binding
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Ralb gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Agrin Interactions at Neuromuscular Junction
- Angiopoietin Signaling
- Bladder Cancer Signaling
- Chemokine Signaling
- CNTF Signaling
- ERK5 Signaling
- FLT3 Signaling in Hematopoietic Progenitor Cells
- Glucocorticoid Receptor Signaling
- GM-CSF Signaling
- JAK/Stat Signaling
- LPS-stimulated MAPK Signaling
- Neuregulin Signaling
- Neurotrophin/TRK Signaling
- NF-κB Signaling
- Oncostatin M Signaling
- PAK Signaling
- PDGF Signaling
- PEDF Signaling
- PPAR Signaling
- Prolactin Signaling
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- TGF-β Signaling
- Thyroid Cancer Signaling
- UVC-Induced MAPK Signaling
- VEGF Family Ligand-Receptor Interactions
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- epithelial neoplasia
- cancer
- lung cancer
- non-small cell lung cancer
- endometriosis
- growth failure
- metastasis
- exencephaly
role in cell
- expression in
- number
- phosphorylation in
- formation
- formation in
- apoptosis
- migration
- survival
- proliferation
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cell surface
- cell periphery
- Nucleus
- Plasma Membrane
- vesicles
- lysosome
- midbody
- cytosol
- endosomal membrane
- nerve ending
- cytoplasmic vesicles
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ralb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein binding
- regulation of exocyst localization
- signal transduction
- positive regulation of epidermal growth factor receptor signaling pathway
- Ras protein signal transduction
- cellular response to starvation
- negative regulation of protein binding
- cell division
- cellular response to exogenous dsRNA
- apoptotic process
- positive regulation of protein phosphorylation
- positive regulation of autophagic vacuole assembly
- regulation of exocyst assembly
- positive regulation of protein serine/threonine kinase activity
- receptor internalization
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- midbody
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- ubiquitin protein ligase binding
- protein binding
- GTPase activity
- small monomeric GTPase activity
- GDP binding
- ATPase binding