Ccng1 Gene Summary [Rat]
Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Involved in several processes, including mitotic G2 DNA damage checkpoint signaling; response to gravity; and syncytium formation. Located in dendrite; neuronal cell body; and perinuclear region of cytoplasm. Used to study hepatocellular carcinoma. Biomarker of breast cancer; hepatocellular carcinoma; muscular atrophy; and traumatic brain injury. Human ortholog(s) of this gene implicated in endocrine gland cancer (multiple); localized osteosarcoma; ovarian cancer (multiple); and sarcoma. Orthologous to human CCNG1 (cyclin G1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccng1 |
| Official Name | cyclin G1 [Source:RGD Symbol;Acc:2295] |
| Ensembl ID | ENSRNOG00000003256 |
| Bio databases IDs | |
| Aliases | cyclin G1 |
| Synonyms | CCNG, CYCG, cyclin G1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ccng1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cyclin box fold superfamily
- Cyclin, N-terminal domain
- protein binding
- domain present in cyclins, TFIIB and Retinoblastoma
Pathways
Biological processes and signaling networks where the Ccng1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast cancer
- liver neoplasia
- COVID-19
- androgenic alopecia
- organismal death
- severe acute respiratory syndrome
- experimentally-induced diabetes
- obesity
role in cell
- survival
- apoptosis
- phosphorylation in
- synthesis in
- proliferation
- quantity
- growth
- formation
- G2/M phase
- G1 phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- perinuclear region
- nuclear foci
- nucleoplasm
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ccng1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- response to gravity
- mitotic cell cycle G2/M transition DNA damage checkpoint
- syncytium formation
- negative regulation of apoptotic process
- response to organic nitrogen
- regulation of cyclin-dependent protein kinase activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- dendrite
- perinuclear region of cytoplasm
- cytoplasm
- cyclin-dependent protein kinase holoenzyme complex
- neuronal cell body
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- cyclin-dependent protein kinase regulator activity
- protein binding