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The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CCNG1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
Cyclin box fold superfamily
Cyclin, N-terminal domain
protein binding
domain present in cyclins, TFIIB and Retinoblastoma
Pathways
Biological processes and signaling networks where the CCNG1 gene in human plays a role, providing insight into its function and relevance in health or disease.
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
Nucleus
perinuclear region
nuclear foci
nucleoplasm
perikaryon
dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CCNG1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
cell division
response to gravity
mitotic cell cycle G2/M transition DNA damage checkpoint
syncytium formation
negative regulation of apoptotic process
response to organic nitrogen
regulation of cyclin-dependent protein kinase activity
Cellular Component
Where in the cell the gene product is active
nucleus
dendrite
perinuclear region of cytoplasm
cytoplasm
cyclin-dependent protein kinase holoenzyme complex
neuronal cell body
nucleoplasm
Molecular Function
What the gene product does at the molecular level
cyclin-dependent protein kinase regulator activity
protein binding
Gene-Specific Assays for Results You Can Trust
Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.