CCNG1 Gene Summary [Human]

The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
CCNG1
Official Name
cyclin G1 [Source:HGNC Symbol;Acc:HGNC:1592]
Ensembl ID
ENSG00000113328
Bio databases IDs NCBI: 900 Ensembl: ENSG00000113328
Aliases cyclin G1
Synonyms CCNG, CYCG, cyclin G1
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CCNG1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Cyclin box fold superfamily
  • Cyclin, N-terminal domain
  • protein binding
  • domain present in cyclins, TFIIB and Retinoblastoma

Pathways

Biological processes and signaling networks where the CCNG1 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • neoplasia
  • breast cancer
  • liver neoplasia
  • COVID-19
  • androgenic alopecia
  • organismal death
  • severe acute respiratory syndrome
  • experimentally-induced diabetes
  • obesity
regulated by
role in cell
  • survival
  • apoptosis
  • phosphorylation in
  • synthesis in
  • proliferation
  • quantity
  • growth
  • formation
  • G2/M phase
  • G1 phase

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • perinuclear region
  • nuclear foci
  • nucleoplasm
  • perikaryon
  • dendrites

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human CCNG1 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • cell division
  • response to gravity
  • mitotic cell cycle G2/M transition DNA damage checkpoint
  • syncytium formation
  • negative regulation of apoptotic process
  • response to organic nitrogen
  • regulation of cyclin-dependent protein kinase activity

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • dendrite
  • perinuclear region of cytoplasm
  • cytoplasm
  • cyclin-dependent protein kinase holoenzyme complex
  • neuronal cell body
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • cyclin-dependent protein kinase regulator activity
  • protein binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.