Stx16 Gene Summary [Rat]
Predicted to enable SNAP receptor activity and syntaxin binding activity. Predicted to be involved in several processes, including endosomal transport; vesicle docking; and vesicle fusion. Is active in synaptic vesicle membrane. Human ortholog(s) of this gene implicated in pseudohypoparathyroidism type 1B. Orthologous to human STX16 (syntaxin 16). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stx16 |
| Official Name | syntaxin 16 [Source:RGD Symbol;Acc:1309423] |
| Ensembl ID | ENSRNOG00000005281 |
| Bio databases IDs | |
| Aliases | syntaxin 16 |
| Synonyms | 4930401D03, 5430410K23Rik, 6330500A18RIK, LOC679159, SYN-16, Syntaxin 16 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Stx16 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNAP receptor
- Helical region found in SNAREs
- protein binding
- SNARE motif
- transporter
- syntaxin binding
Pathways
Biological processes and signaling networks where the Stx16 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- nonalcoholic fatty liver disease
- pseudohypoparathyroidism type 1B
role in cell
- accumulation in
- formation in
- formation
- accumulation
- transport in
- cytokinesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi-endosome fractions
- synaptic vesicle membrane
- intracellular membrane-bounded organelle
- intracellular space
- perinuclear region
- cellular membrane
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- midbody
- cytosol
- Golgi membrane
- trans Golgi network
- growth cone
- early endosomes
- Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Stx16 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle fusion
- vesicle docking
- intracellular protein transport
- retrograde transport, endosome to Golgi
- endocytic recycling
Cellular Component
Where in the cell the gene product is active
- Golgi membrane
- Golgi apparatus
- trans-Golgi network
- perinuclear region of cytoplasm
- focal adhesion
- cytoplasm
- intracellular membrane-bounded organelle
- SNARE complex
- cytosol
- endomembrane system
- synaptic vesicle membrane
- Golgi cisterna
- trans-Golgi network membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- syntaxin binding
- SNAP receptor activity
- SNARE binding