Ptpn12 Gene Summary [Rat]
Enables protein tyrosine phosphatase activity. Involved in tissue regeneration. Predicted to be located in cytosol and podosome. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human PTPN12 (protein tyrosine phosphatase non-receptor type 12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptpn12 |
| Official Name | protein tyrosine phosphatase, non-receptor type 12 [Source:RGD Symbol;Acc:620894] |
| Ensembl ID | ENSRNOG00000013135 |
| Bio databases IDs | |
| Aliases | protein tyrosine phosphatase, non-receptor type 12 |
| Synonyms | P19-PTP, protein tyrosine phosphatase non-receptor type 12, protein tyrosine phosphatase, non-receptor type 12, PTPG1, PTP-P19, PTP-PEST, RKPTP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ptpn12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- non-membrane spanning protein tyrosine phosphatase
- RXXs motif
- protein-tyrosine-phoshatase
- catalytic domain
- Protein tyrosine phosphatase, catalytic domain
- PTP_DSP_cys
- protein binding
- proline rich domain
- Protein tyrosine phosphatase, catalytic domain motif
- SH3-domain binding
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- Protein-tyrosine phosphatase
- protein phosphatase
- phosphatase
- pro domain
Pathways
Biological processes and signaling networks where the Ptpn12 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- laryngeal squamous cell carcinoma
- renal cell carcinoma
- renal cell cancer
- pancreatic epithelial cancer
- colon cancer
- organismal death
- colorectal cancer
- epithelial cancer
- epithelial neoplasia
role in cell
- migration
- expression in
- phosphorylation in
- proliferation
- differentiation
- activation in
- growth
- quantity
- production in
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- perinuclear region
- cellular membrane
- podosomes
- actin cytoskeleton
- cytosol
- endoplasmic reticulum membrane
- nucleoplasm
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ptpn12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein dephosphorylation
- cellular response to epidermal growth factor stimulus
- negative regulation of platelet-derived growth factor receptor-beta signaling pathway
- regulation of epidermal growth factor receptor signaling pathway
- tissue regeneration
- peptidyl-tyrosine dephosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- focal adhesion
- cytoplasm
- cytosol
- cell projection
- podosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- phosphoprotein phosphatase activity
- protein binding
- non-membrane spanning protein tyrosine phosphatase activity
- protein tyrosine phosphatase activity
- SH3 domain binding