Abcg8 Gene Summary [Rat]
Predicted to enable ATPase-coupled transmembrane transporter activity and protein heterodimerization activity. Predicted to contribute to ATP binding activity; ATP hydrolysis activity; and cholesterol transfer activity. Involved in several processes, including cholesterol homeostasis; response to muscle activity; and triglyceride homeostasis. Predicted to be located in apical plasma membrane. Predicted to be part of ATP-binding activity cassette (ABC) transporter complex and receptor complex. Predicted to be active in plasma membrane. Biomarker of cholestasis and metabolic dysfunction-associated steatotic liver disease. Human ortholog(s) of this gene implicated in arteriosclerosis; familial hyperlipidemia; obesity; and sitosterolemia. Orthologous to human ABCG8 (ATP binding cassette subfamily G member 8). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Abcg8 |
| Official Name | ATP binding cassette subfamily G member 8 [Source:RGD Symbol;Acc:620300] |
| Ensembl ID | ENSRNOG00000005420 |
| Bio databases IDs | |
| Aliases | ATP binding cassette subfamily G member 8 |
| Synonyms | 1300003C16Rik, ATP binding cassette subfamily G member 8, GBD4, sterolin-2, STSL, STSL1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Abcg8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ABC-2 type transporter
- ATPase activity, coupled to transmembrane movement of substances
- FeS assembly ATPase SufC
- The Eye Pigment Precursor Transporter (EPP) Family protein
- lipoprotein releasing system, ATP-binding protein
- walker type B motif
- ATP binding
- walker type A motif
- protein binding
- nitrate transport ATP-binding subunits C and D
- ATPase
- ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system
- heme ABC exporter, ATP-binding protein CcmA
- lipid transporter
- nucleotide-binding domain
- LPS export ABC transporter ATP-binding protein
- cobalt transport protein ATP-binding subunit
- energy-coupling factor transporter ATPase
- nickel import ATP-binding protein NikE
- ABC transporter
- protein heterodimerization
- P-loop containing Nucleoside Triphosphate Hydrolases
- transporter
Pathways
Biological processes and signaling networks where the Abcg8 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic disorder
- heart disease
- cardiovascular disorder
- cholestasis
- hypercholesterolemia
- cholelithiasis
- sitosterolemia type 1
- primary genetic hyperlipidemia
- myocardial infarction
- nutritionally induced type 2 diabetes
regulates
- triacylglycerol
- LDL/cholesterol
- cholesterol
- fatty acid
- ABCG8
- sitosterol
- C20-ceramide
- sterol
- sphingosine-1-phosphate
- campesterol
role in cell
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cellular membrane
- Endoplasmic Reticulum
- apical membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Abcg8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to muscle activity
- transmembrane transport
- response to nutrient
- response to xenobiotic stimulus
- negative regulation of intestinal cholesterol absorption
- cholesterol homeostasis
- negative regulation of intestinal phytosterol absorption
- sterol transport
- phospholipid transport
- cholesterol efflux
- intestinal cholesterol absorption
- triglyceride homeostasis
Cellular Component
Where in the cell the gene product is active
- receptor complex
- ATP-binding cassette (ABC) transporter complex
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- ATPase activity, coupled to transmembrane movement of substances
- protein binding
- metal ion binding
- protein heterodimerization activity