Abcg5 Gene Summary [Rat]
Predicted to enable ATPase-coupled transmembrane transporter activity and protein heterodimerization activity. Predicted to contribute to ATP binding activity; ATP hydrolysis activity; and cholesterol transfer activity. Involved in several processes, including cholesterol homeostasis; response to muscle activity; and triglyceride homeostasis. Predicted to be located in apical part of cell and membrane. Predicted to be part of ATP-binding activity cassette (ABC) transporter complex and receptor complex. Predicted to be active in apical plasma membrane. Used to study sitosterolemia. Biomarker of cholestasis; metabolic dysfunction-associated steatotic liver disease; and obesity. Human ortholog(s) of this gene implicated in arteriosclerosis; sitosterolemia; and sitosterolemia 2. Orthologous to human ABCG5 (ATP binding cassette subfamily G member 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Abcg5 |
| Official Name | ATP binding cassette subfamily G member 5 [Source:RGD Symbol;Acc:620298] |
| Ensembl ID | ENSRNOG00000005250 |
| Bio databases IDs | |
| Aliases | ATP binding cassette subfamily G member 5 |
| Synonyms | ATP binding cassette subfamily G member 5, cmp, sterolin-1, STSL, STSL2, trac |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Abcg5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ABC-2 type transporter
- ATPase activity, coupled to transmembrane movement of substances
- The Eye Pigment Precursor Transporter (EPP) Family protein
- lipoprotein releasing system, ATP-binding protein
- AAA ATPase domain
- walker type B motif
- ATP binding
- walker type A motif
- protein binding
- ATPase
- ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system
- heme ABC exporter, ATP-binding protein CcmA
- lipid transporter
- nucleotide-binding domain
- LPS export ABC transporter ATP-binding protein
- cobalt transport protein ATP-binding subunit
- energy-coupling factor transporter ATPase
- ABC transporter
- protein heterodimerization
- P-loop containing Nucleoside Triphosphate Hydrolases
- transporter
- ATPases associated with a variety of cellular activities
Pathways
Biological processes and signaling networks where the Abcg5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cholecystitis
- diabetes mellitus
- hypercholesterolemia
- sitosterolemia
- sitosterolemia type 2
- nutritionally induced type 2 diabetes
- insulin resistance
- cholelithiasis
- primary biliary cirrhosis
- gallstone
regulates
- cholesterol
- phospholipid
- campesterol
- ABCG5
- phytosterol derivative
- C20-ceramide
- sphingosine-1-phosphate
- sterol
- sitosterol
- INS
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- apical compartment
- cellular membrane
- Endoplasmic Reticulum
- apical cell surfaces
- apical membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Abcg5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to muscle activity
- transmembrane transport
- response to nutrient
- negative regulation of intestinal cholesterol absorption
- response to xenobiotic stimulus
- cholesterol homeostasis
- negative regulation of intestinal phytosterol absorption
- sterol transport
- intestinal cholesterol absorption
- cholesterol efflux
- triglyceride homeostasis
- response to ionizing radiation
Cellular Component
Where in the cell the gene product is active
- receptor complex
- apical plasma membrane
- ATP-binding cassette (ABC) transporter complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- ATPase activity, coupled to transmembrane movement of substances
- protein binding
- protein heterodimerization activity
- metal ion binding