Abcg8 Gene Summary [Mouse]
Enables protein heterodimerization activity. Contributes to cholesterol transfer activity. Involved in cholesterol efflux. Acts upstream of or within cholesterol homeostasis and phospholipid transport. Located in apical plasma membrane. Part of receptor complex. Is expressed in several structures, including alimentary system; brain; hemolymphoid system; liver and biliary system; and male reproductive gland or organ. Used to study sitosterolemia. Human ortholog(s) of this gene implicated in arteriosclerosis; familial hyperlipidemia; obesity; and sitosterolemia. Orthologous to human ABCG8 (ATP binding cassette subfamily G member 8). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Abcg8 |
| Official Name | ATP binding cassette subfamily G member 8 [Source:MGI Symbol;Acc:MGI:1914720] |
| Ensembl ID | ENSMUSG00000024254 |
| Bio databases IDs | |
| Aliases | ATP binding cassette subfamily G member 8 |
| Synonyms | 1300003C16Rik, ATP binding cassette subfamily G member 8, GBD4, sterolin-2, STSL, STSL1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Abcg8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ABC-2 type transporter
- ATPase activity, coupled to transmembrane movement of substances
- FeS assembly ATPase SufC
- The Eye Pigment Precursor Transporter (EPP) Family protein
- lipoprotein releasing system, ATP-binding protein
- walker type B motif
- ATP binding
- walker type A motif
- protein binding
- nitrate transport ATP-binding subunits C and D
- ATPase
- ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system
- heme ABC exporter, ATP-binding protein CcmA
- lipid transporter
- nucleotide-binding domain
- LPS export ABC transporter ATP-binding protein
- cobalt transport protein ATP-binding subunit
- energy-coupling factor transporter ATPase
- nickel import ATP-binding protein NikE
- ABC transporter
- protein heterodimerization
- P-loop containing Nucleoside Triphosphate Hydrolases
- transporter
Pathways
Biological processes and signaling networks where the Abcg8 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic disorder
- heart disease
- cardiovascular disorder
- cholestasis
- hypercholesterolemia
- cholelithiasis
- sitosterolemia type 1
- primary genetic hyperlipidemia
- myocardial infarction
- nutritionally induced type 2 diabetes
regulates
- triacylglycerol
- LDL/cholesterol
- cholesterol
- fatty acid
- ABCG8
- sitosterol
- C20-ceramide
- sterol
- sphingosine-1-phosphate
- campesterol
role in cell
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cellular membrane
- Endoplasmic Reticulum
- apical membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Abcg8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to muscle activity
- transmembrane transport
- response to nutrient
- response to xenobiotic stimulus
- negative regulation of intestinal cholesterol absorption
- cholesterol homeostasis
- negative regulation of intestinal phytosterol absorption
- sterol transport
- phospholipid transport
- cholesterol efflux
- intestinal cholesterol absorption
- triglyceride homeostasis
Cellular Component
Where in the cell the gene product is active
- receptor complex
- ATP-binding cassette (ABC) transporter complex
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- ATPase activity, coupled to transmembrane movement of substances
- protein binding
- metal ion binding
- protein heterodimerization activity