SULF2 Gene Summary [Human]
Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM, Mar 2008]
Details
| Type | Processed Transcript |
| Official Symbol | SULF2 |
| Official Name | sulfatase 2 [Source:HGNC Symbol;Acc:HGNC:20392] |
| Ensembl ID | ENSG00000196562 |
| Bio databases IDs | |
| Aliases | sulfatase 2 |
| Synonyms | 2010004N24Rik, HSULF-2, mKIAA1247, MSulf-2, sulfatase 2, sulph2, sulphatase 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SULF2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alkaline phosphatases and sulfatases
- N-acetylglucosamine-6-sulfatase
- Sulfatase
- enzyme
- Sulfatase protein
- arylsulfatase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- neoplasia
- metastasis
- premature ejaculation
- epithelial cancer
- epithelial neoplasia
- severe preeclampsia
- growth failure
- hepatocellular carcinoma
- liver cancer
role in cell
- expression in
- phosphorylation in
- apoptosis
- activation in
- sprouting
- function
- proliferation
- binding
- cell death
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- Endoplasmic Reticulum
- Golgi stacks
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SULF2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of fibroblast growth factor receptor signaling pathway
- glial cell-derived neurotrophic factor receptor signaling pathway
- glomerular filtration
- innervation
- response to wounding
- positive regulation of canonical Wnt receptor signaling pathway
- chondrocyte development
- embryonic skeletal system development
- bone development
- glomerular basement membrane development
- kidney development
- esophagus smooth muscle contraction
- positive regulation of Wnt receptor signaling pathway
- heparan sulfate proteoglycan metabolic process
- regulation of hepatocyte proliferation
- cartilage development
- positive regulation vascular endothelial growth factor production
Cellular Component
Where in the cell the gene product is active
- extracellular space
- endoplasmic reticulum
- extracellular region
- Golgi stack
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- glycosaminoglycan binding
- calcium ion binding
- arylsulfatase activity
- N-acetylglucosamine-6-sulfatase activity