Septin5 Gene Summary [Rat]
Enables several functions, including guanyl ribonucleotide binding activity; protein homodimerization activity; and syntaxin binding activity. Involved in positive regulation of exocytosis. Located in cleavage furrow; stress fiber; and synaptic vesicle. Part of septin complex. Orthologous to human SEPTIN5 (septin 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Septin5 |
| Official Name | septin 5 [Source:RGD Symbol;Acc:621763] |
| Ensembl ID | ENSRNOG00000029912 |
| Bio databases IDs | |
| Aliases | septin 5 |
| Synonyms | CDCREL, CDCREL-1, CDCrel-1A, GPIbB, GPIb-beta, GPIb-β, H5, HCDCREL-1, PNUTL1, Sep5, SEPT5 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Septin5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RXXs motif
- GTPase
- enzyme
- protein binding
- identical protein binding
- Septin
- phosphatidylinositol binding
- phosphorylation site
- syntaxin binding
- GTP binding
- GTPase domain
- GDP binding
- protein homodimerization
- structural molecule
- GTP binding motif, P-loop
- Serine Proline motif
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Septin5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Turner syndrome
- pemphigus vulgaris
- Huntington disease
- Klinefelter syndrome
- androgenic alopecia
- neurodegeneration
role in cell
- function
- aggregation
- exocytosis by
- loss
- targeting
- docking
- exocytosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- presynaptic regions
- cell cortex
- Plasma Membrane
- synaptic vesicles
- synaptosomes
- synapse
- actin stress fibers
- cleavage furrow
- perikaryon
- dendrites
- axon terminals
- synaptic vesicle fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Septin5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- social behavior
- synaptic vesicle targeting
- regulation of synaptic vesicle exocytosis
- protein localization
- regulation of exocytosis
- adult behavior
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- cell division site
- synaptic vesicle
- septin complex
- plasma membrane
- septin ring
Molecular Function
What the gene product does at the molecular level
- GTP binding
- identical protein binding
- protein binding
- GTPase activity
- structural molecule activity
- binding, bridging