Septin11 Gene Summary [Rat]
Predicted to enable GTPase activity and molecular adaptor activity. Involved in regulation of synapse organization. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic specialization of symmetric synapse. Orthologous to human SEPTIN11 (septin 11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Septin11 |
| Official Name | septin 11 [Source:RGD Symbol;Acc:1307405] |
| Ensembl ID | ENSRNOG00000002182 |
| Bio databases IDs | |
| Aliases | septin 11 |
| Synonyms | 6230410I01Rik, D5Ertd606e, FLJ10849, SEPT11, Sept6, Septin 6 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Septin11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTPase domain
- protein binding
- Septin
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Septin11 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- organismal death
- hepatocellular carcinoma
- liver cancer
- metastasis
role in cell
- expression in
- migration
- phosphorylation in
- activation in
- disruption
- density
- binucleation
- arborization
- rearrangement
- bundling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- glutaminergic synapse
- spiny branchlet
- type-II synapse
- organelle
- postsynaptic region
- midbody
- cytoplasmic bridges
- cytosol
- nucleoli
- dendritic spine neck
- synapse
- actin stress fibers
- cleavage furrow
- dendrites
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Septin11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of synapse organization
- protein localization
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- cell division site
- stress fiber
- dendritic spine
- septin complex
- axon
- septin ring
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- binding, bridging