Usp2 Gene Summary [Rat]
Enables cysteine-type deubiquitinase activity. Involved in negative regulation of skeletal muscle tissue development; positive regulation of skeletal muscle tissue development; and protein deubiquitination. Located in centrosome; nucleus; and perinuclear region of cytoplasm. Orthologous to human USP2 (ubiquitin specific peptidase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Usp2 |
| Official Name | ubiquitin specific peptidase 2 [Source:RGD Symbol;Acc:621073] |
| Ensembl ID | ENSRNOG00000006663 |
| Bio databases IDs | |
| Aliases | ubiquitin specific peptidase 2 |
| Synonyms | B930035K21Rik, Testis specific ubp, ubiquitin specific peptidase 2, UBP41, Ubp69, UBP-t, USP9 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Usp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- cysteine endopeptidase
- peptidase
- Ubiquitin carboxyl-terminal hydrolase
- active site
- ubiquitin-specific protease
- protein binding
- identical protein binding
- Peptidase_C19
- cyclin binding
Pathways
Biological processes and signaling networks where the Usp2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- tumorigenesis
- Huntington disease
- survival
- refractive error
- esophageal squamous cell carcinoma
- esophageal squamous cell cancer
- prostatic adenocarcinoma
- prostate cancer
- hyperactive behavior
role in cell
- phosphorylation in
- apoptosis
- cell viability
- expression in
- degradation in
- accumulation in
- proliferation
- replication in
- invasion by
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cellular membrane
- Nucleus
- centrosome
- nucleoplasm
- perinuclear space
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Usp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle organ development
- protein deubiquitination
- negative regulation of transcription from RNA polymerase II promoter
- circadian regulation of gene expression
- locomotor rhythm
- proteolysis
- entrainment of circadian clock by photoperiod
- circadian behavior
- protein stabilization
- positive regulation of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- centrosome
- perinuclear region of cytoplasm
- cytoplasm
- membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- identical protein binding
- ubiquitin protein ligase binding
- protein binding
- metal ion binding
- cysteine-type endopeptidase activity
- cyclin binding