Rdh10 Gene Summary [Rat]
Predicted to enable all-trans-retinol dehydrogenase (NAD+) activity. Involved in positive regulation of retinoic acid biosynthetic process. Predicted to be located in cytoplasm and membrane. Predicted to be active in lipid droplet. Orthologous to human RDH10 (retinol dehydrogenase 10). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rdh10 |
| Official Name | retinol dehydrogenase 10 [Source:RGD Symbol;Acc:727793] |
| Ensembl ID | ENSRNOG00000006681 |
| Bio databases IDs | |
| Aliases | retinol dehydrogenase 10 |
| Synonyms | 3110069K09Rik, 4921506A21RIK, D1Ertd762e, m366Asp, retinol dehydrogenase 10, retinol dehydrogenase 10 (all-trans), SDR16C4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rdh10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NADP-retinol dehydrogenase
- Rossmann-fold NAD(P)(+)-binding proteins
- 11-cis-retinol dehydrogenase
- retinol dehydrogenase
- enzyme
- protein binding
- short chain dehydrogenase
Pathways
Biological processes and signaling networks where the Rdh10 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- asthma
- cleft face
- hypoplasia
- Sézary syndrome
- cardiac fibrosis
- growth failure
- heart failure
- syndactyly
- persistent truncus arteriosus
role in cell
- apoptosis
- signaling in
- synthesis in
- differentiation
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cellular membrane
- contractile rings
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rdh10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- primary lung bud formation
- positive regulation of retinoic acid biosynthetic process
- embryonic camera-type eye development
- neural crest cell development
- retinol metabolic process
- bud elongation involved in lung branching
- nose development
- retinal metabolic process
- visual perception
- embryonic viscerocranium morphogenesis
- retinoic acid biosynthetic process
- gonad development
- retinoid metabolic process
- metanephros development
- in utero embryonic development
- ear development
- embryonic forelimb morphogenesis
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- lipid particle
- nucleus
- cytoplasm
- membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- retinol dehydrogenase activity
- NADP-retinol dehydrogenase activity
- oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor