Dhrs3 Gene Summary [Rat]
Predicted to enable all-trans-retinol dehydrogenase (NAD+) activity and all-trans-retinol dehydrogenase (NADP+) activity. Predicted to be involved in retinol metabolic process. Predicted to act upstream of or within several processes, including heart morphogenesis; negative regulation of retinoic acid receptor signaling pathway; and regulation of ossification. Predicted to be located in membrane. Orthologous to human DHRS3 (dehydrogenase/reductase 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dhrs3 |
| Official Name | dehydrogenase/reductase 3 [Source:RGD Symbol;Acc:1305584] |
| Ensembl ID | ENSRNOG00000015736 |
| Bio databases IDs | |
| Aliases | dehydrogenase/reductase 3 |
| Synonyms | CNALPTC1, DD83.1, dehydrogenase/reductase 3, ineligibledhrs3, RDH17, Retinal Short Chain Dehydrogenase/Reductase, Retinal short-chain dehydrogenase/reductase 1, retSDR1, Rsdr1, SDR1, SDR16C1, Short-chain dehydrogenase/reductase member 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dhrs3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NADP-retinol dehydrogenase
- polyketide synthase keto reductase domain
- Rossmann-fold NAD(P)(+)-binding proteins
- electron carrier
- nucleotide binding
- sepiapterin reductase
- retinol dehydrogenase
- KR domain
- enzyme
- short chain dehydrogenase
Pathways
Biological processes and signaling networks where the Dhrs3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- eyelids open at birth
- diabetic nephropathy
- septic shock
- micrognathia
- growth failure
- double outlet right ventricle
- ventricular septal defect
- atrial septal defect
regulates
- retinol
- RDH10
- retinyl ester
- RDH
- retinoid
- all-trans-retinyl esters
role in cell
- ossification by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- perinuclear region
- cellular membrane
- Endoplasmic Reticulum
- contractile rings
- lipid droplets
- endoplasmic reticulum membrane
- photoreceptor outer segments
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dhrs3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of retinoic acid receptor signaling pathway
- retinoid metabolic process
- negative regulation of retinoic acid receptor signaling pathway
- palate development
- outflow tract morphogenesis
- bone morphogenesis
- retinol metabolic process
- cardiac septum morphogenesis
- visual perception
- regulation of ossification
Cellular Component
Where in the cell the gene product is active
- lipid particle
- endoplasmic reticulum membrane
- photoreceptor outer segment membrane
Molecular Function
What the gene product does at the molecular level
- nucleotide binding
- retinol dehydrogenase activity
- NADP-retinol dehydrogenase activity
- electron carrier activity