Rdh10 Gene Summary [Mouse]
Enables all-trans-retinol dehydrogenase (NAD+) activity. Acts upstream of or within several processes, including chordate embryonic development; embryonic forelimb morphogenesis; and respiratory system development. Located in membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human RDH10 (retinol dehydrogenase 10). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rdh10 |
| Official Name | retinol dehydrogenase 10 (all-trans) [Source:MGI Symbol;Acc:MGI:1924238] |
| Ensembl ID | ENSMUSG00000025921 |
| Bio databases IDs | |
| Aliases | retinol dehydrogenase 10 (all-trans) |
| Synonyms | 3110069K09Rik, 4921506A21RIK, D1Ertd762e, m366Asp, retinol dehydrogenase 10, retinol dehydrogenase 10 (all-trans), SDR16C4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rdh10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NADP-retinol dehydrogenase
- Rossmann-fold NAD(P)(+)-binding proteins
- 11-cis-retinol dehydrogenase
- retinol dehydrogenase
- enzyme
- protein binding
- short chain dehydrogenase
Pathways
Biological processes and signaling networks where the Rdh10 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- asthma
- cleft face
- hypoplasia
- Sézary syndrome
- cardiac fibrosis
- growth failure
- heart failure
- syndactyly
- persistent truncus arteriosus
phenotypes
- abnormal autopod morphology
- abnormal cardiac outflow tract development
- abnormal cardiovascular system physiology
- abnormal cerebral cortex morphology
- abnormal cranial ganglia morphology
- abnormal craniofacial development
- abnormal craniofacial morphology
- abnormal digit development
- abnormal dorsal aorta morphology
- abnormal embryo development
- abnormal embryo turning
- abnormal embryonic tissue morphology
- abnormal eye development
- abnormal eye morphology
- abnormal forebrain morphology
- abnormal forelimb bud morphology
- abnormal forelimb morphology
- abnormal fourth pharyngeal arch morphology
- abnormal frontonasal prominence morphology
- abnormal geniculate ganglion morphology
- abnormal glossopharyngeal ganglion morphology
- abnormal heart development
- abnormal heart looping
- abnormal heart tube morphology
- abnormal hindbrain development
- abnormal intestine morphology
- abnormal lateral nasal prominence morphology
- abnormal limb morphology
- abnormal liver parenchyma morphology
- abnormal lung development
- abnormal maxillary prominence morphology
- abnormal medial nasal prominence morphology
- abnormal mesoderm development
- abnormal metanephros morphology
- abnormal midgut morphology
- abnormal nasal placode morphology
- abnormal optic vesicle formation
- abnormal otic vesicle development
- abnormal otic vesicle morphology
- abnormal pharyngeal arch morphology
- abnormal reproductive system development
- abnormal retina morphology
- abnormal rostral-caudal body axis extension
- abnormal second pharyngeal arch artery morphology
- abnormal sixth pharyngeal arch morphology
- abnormal stomach morphology
- abnormal third pharyngeal arch morphology
- abnormal trigeminal ganglion morphology
- abnormal vagus ganglion morphology
- abnormal vestibulocochlear ganglion morphology
- abnormal vitamin A metabolism
- absent cornea
- absent fourth pharyngeal arch
- absent lung buds
- absent lungs
- absent nasal cavity
- absent nasal septum
- absent pancreas
- absent pharyngeal arches
- absent radius
- absent sixth pharyngeal arch
- absent sixth pharyngeal arch artery
- absent third pharyngeal arch
- absent third pharyngeal arch artery
- brachydactyly
- cardiac edema
- caudal body truncation
- circling
- decreased embryo size
- decreased somite size
- decreased ventral retina size
- embryo tissue necrosis
- embryonic growth arrest
- embryonic growth retardation
- embryonic lethality during organogenesis complete penetrance
- facial cleft
- failure of heart looping
- frontonasal prominence hypoplasia
- fused pharyngeal arches
- hemorrhage
- impaired branching involved in trachea morphogenesis
- incomplete embryo turning
- lethality during fetal growth through weaning complete penetrance
- liver hypoplasia
- midline facial cleft
- no abnormal phenotype detected
- pancreas hypoplasia
- persistent truncus arteriosis
- pulmonary hypoplasia
- renal hypoplasia
- small forelimb buds
- small gonad
- small lens
- small liver
- small otic vesicle
- small stomach
- syndactyly
role in cell
- apoptosis
- signaling in
- synthesis in
- differentiation
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cellular membrane
- contractile rings
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rdh10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- primary lung bud formation
- positive regulation of retinoic acid biosynthetic process
- embryonic camera-type eye development
- neural crest cell development
- retinol metabolic process
- bud elongation involved in lung branching
- nose development
- retinal metabolic process
- visual perception
- embryonic viscerocranium morphogenesis
- retinoic acid biosynthetic process
- gonad development
- retinoid metabolic process
- metanephros development
- in utero embryonic development
- ear development
- embryonic forelimb morphogenesis
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- lipid particle
- nucleus
- cytoplasm
- membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- retinol dehydrogenase activity
- NADP-retinol dehydrogenase activity
- oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor