Ambp Gene Summary [Rat]
Enables serine-type endopeptidase inhibitor activity. Involved in protein catabolic process. Located in cell surface and extracellular space. Biomarker of calcium oxalate nephrolithiasis. Human ortholog(s) of this gene implicated in acute kidney failure and adult respiratory distress syndrome. Orthologous to human AMBP (alpha-1-microglobulin/bikunin precursor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ambp |
| Official Name | alpha-1-microglobulin/bikunin precursor [Source:RGD Symbol;Acc:2102] |
| Ensembl ID | ENSRNOG00000006889 |
| Bio databases IDs | |
| Aliases | alpha-1-microglobulin/bikunin precursor |
| Synonyms | alpha-1-microglobulin/bikunin precursor, ASPI, Bikunin, EDC1, HCP, HI-30, IATIL, Intin4, ITI, ITIL, ITILC, UTI, α 1 microglobulin/bikunin, α-1-microglobulin/bikunin precursor |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ambp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Kunitz/Bovine pancreatic trypsin inhibitor (BPTI) domain
- lipocalin/cytosolic fatty acid-binding protein family
- NADH or NADPH:heme protein oxidoreductase
- extracellular matrix binding
- serine protease inhibitor activity
- antioxidant enzyme
- protein binding
- heme binding
- Lipocalin / cytosolic fatty-acid binding protein family
- glycosaminoglycan binding
- binding protein
- protein homodimerization
- Kunitz protease inhibitor domain
- carbohydrate binding
- IgA binding
- transporter
Pathways
Biological processes and signaling networks where the Ambp gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- depressive disorder
- mood disorder
- acute kidney injury
- diabetic nephropathy
- lung adenocarcinoma
- lung adenocarcinoma formation
- senile lentigo
- cholangiocarcinoma
- liver cancer
- metastasis
role in cell
- expression in
- quantity
- adhesion
- abnormal morphology
- destruction
- response by
- fertilization
- lack
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- perinuclear region
- Nucleus
- Plasma Membrane
- Mitochondria
- granules
- apical cell surfaces
- extracellular matrix
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ambp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- female pregnancy
- heme catabolic process
- cell adhesion
- negative regulation of JNK cascade
- negative regulation of immune response
Cellular Component
Where in the cell the gene product is active
- extracellular space
- nuclear membrane
- extracellular vesicular exosome
- blood microparticle
- cytosol
- endoplasmic reticulum
- extracellular region
- mitochondrial inner membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity
- calcium oxalate binding
- protein homodimerization activity
- protein binding
- oxidoreductase activity
- IgA binding
- carbohydrate binding
- heme binding
- calcium channel inhibitor activity