Cyp51 Gene Summary [Rat]
Enables sterol 14-demethylase activity. Involved in several processes, including cholesterol biosynthetic process via 24,25-dihydrolanosterol; positive regulation of oocyte development; and response to human chorionic gonadotropin. Located in acrosomal vesicle. Biomarker of diabetes mellitus. Orthologous to human CYP51A1 (cytochrome P450 family 51 subfamily A member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cyp51 |
| Official Name | cytochrome P450, family 51 [Source:RGD Symbol;Acc:2481] |
| Ensembl ID | ENSRNOG00000007234 |
| Bio databases IDs | |
| Aliases | cytochrome P450, family 51 |
| Synonyms | Arr, CP51, CYP51, CYP51A, Cyp51b, CYPL1, CYPLI, Cytochrome P450 51, cytochrome P450, family 51, cytochrome P450 family 51 subfamily A member 1, Cytochrome P450, Family 51, Subfamily A, Polypeptide 1, LANOSTEROL 14-alpha DEMETHYLASE, LANOSTEROL 14-α DEMETHYLASE, LDM, P450-14DM, P450L1, P450LI, RATCP14DM, Similar to cyp51, Sterol 14-alpha Demethylase, Sterol 14-α Demethylase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cyp51 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytochrome P450 (CYP) superfamily
- Cytochrome P450
- reduced flavin or flavoprotein:oxygen oxidoreductase
- unspecific monooxygenase
- sterol 14-demethylase
- transmembrane domain
- enzyme
- heme binding
Pathways
Biological processes and signaling networks where the Cyp51 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- lymphoma
- neutropenia
- chronic obstructive pulmonary disease
- bacterial disease
- postoperative infection
- febrile neutropenia
- cancer
- HIV infection
- acquired immunodeficiency syndrome
role in cell
- expression in
- growth
- maturation
- adipogenesis in
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- outer membranes
- Nucleus
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- endoplasmic reticulum membrane
- microsome
- acrosome
- medial Golgi cisternae
- cis Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cyp51 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of protein secretion
- cholesterol biosynthetic process
- negative regulation of beta-amyloid clearance
- negative regulation of protein catabolic process
- steroid biosynthetic process
- sterol metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
Molecular Function
What the gene product does at the molecular level
- oxidoreductase activity
- iron ion binding
- sterol 14-demethylase activity
- heme binding