Baat Gene Summary [Rat]
Enables glycine N-choloyltransferase activity. Involved in animal organ regeneration; bile acid conjugation; and liver development. Located in cytosol and peroxisome. Human ortholog(s) of this gene implicated in disease of metabolism. Orthologous to human BAAT (bile acid-CoA:amino acid N-acyltransferase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Baat |
| Official Name | bile acid CoA:amino acid N-acyltransferase [Source:RGD Symbol;Acc:2190] |
| Ensembl ID | ENSRNOG00000007395 |
| Bio databases IDs | |
| Aliases | bile acid CoA:amino acid N-acyltransferase |
| Synonyms | BACAT, BACD1, BAT, bile acid-CoA:amino acid N-acyltransferase, bile acid-Coenzyme A: amino acid N-acyltransferase, FHCA3, glycine N-choloyltransferase, HCHO, kan-1, Nat |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Baat often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- glycine N-choloyltransferase
- N-acyltransferase
- alpha/beta hydrolases
- ADP-dependent medium-chain-acyl-CoA hydrolase
- Acyl-CoA thioester hydrolase/BAAT N-terminal region
- enzyme
- protein binding
- transferase, transferring acyl groups
- acyl-CoA hydrolase
Pathways
Biological processes and signaling networks where the Baat gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bile acid conjugation defect type 1
- familial hypercholanemia
- progressive familial intrahepatic cholestasis type 1
- streptozotocin-induced diabetic nephropathy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- peroxisomal matrix
- intracellular membrane-bounded organelle
- cytosol
- peroxisomes
- peroxisome-enriched fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Baat gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- acyl-CoA metabolic process
- liver development
- taurine metabolic process
- bile acid conjugation
- organ regeneration
- bile acid biosynthetic process
- bile acid metabolic process
- fatty acid metabolic process
- glycine metabolic process
Cellular Component
Where in the cell the gene product is active
- peroxisome
- intracellular membrane-bounded organelle
- cytosol
- peroxisomal matrix
Molecular Function
What the gene product does at the molecular level
- transferase activity, transferring acyl groups
- protein binding
- long-chain acyl-CoA hydrolase activity
- very long chain acyl-CoA hydrolase activity
- glycine N-choloyltransferase activity
- medium-chain acyl-CoA hydrolase activity
- choloyl-CoA hydrolase activity
- N-acyltransferase activity
- acyl-CoA hydrolase activity
- carboxylic ester hydrolase activity