C1r Gene Summary [Rat]
Predicted to enable several functions, including calcium ion binding activity; identical protein binding activity; and serine-type endopeptidase activity. Predicted to be involved in zymogen activation. Predicted to be active in blood microparticle. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome periodontal type 1. Orthologous to human C1R (complement C1r). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | C1r |
| Official Name | complement C1r [Source:RGD Symbol;Acc:1309091] |
| Ensembl ID | ENSRNOG00000011796 |
| Bio databases IDs | |
| Aliases | complement C1r |
| Synonyms | C1ra, complement C1r, COMPLEMENT COMPONENT 1, R SUBCOMPONENT, EDS8, EDSPD1, Similar to c1r |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat C1r often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Trypsin-like serine protease
- Tryp_SPc
- CUB-EGF module pair
- peptidase
- serine protease domain
- calcium ion binding
- protein binding
- identical protein binding
- EGF-like domain
- EGF_CA
- CCP
- trypsin
- serine endopeptidase
- CUB
- serine-type peptidase
- Sushi repeat (SCR repeat)
- Coagulation Factor Xa inhibitory site
- SUSHI repeat
Pathways
Biological processes and signaling networks where the C1r gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- systemic lupus erythematosus
- angioimmunoblastic T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- hepatocellular carcinoma
- liver cancer
- periodontal type Ehlers-Danlos syndrome
- Alzheimer disease
- prostate cancer
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat C1r gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- zymogen activation
- immune response
- innate immune response
- complement activation, classical pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- blood microparticle
- extracellular region
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- calcium ion binding
- serine-type peptidase activity
- serine-type endopeptidase activity