C1s Gene Summary [Rat]
Predicted to enable identical protein binding activity and serine-type endopeptidase activity. Involved in glial cell differentiation and response to cAMP. Located in extracellular region. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome periodontal type 2. Orthologous to human C1S (complement C1s). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | C1s |
| Official Name | complement C1s [Source:RGD Symbol;Acc:619983] |
| Ensembl ID | ENSRNOG00000011971 |
| Bio databases IDs | |
| Aliases | complement C1s |
| Synonyms | C1s2, C1sb, complement C1s, complement component 1, s subcomponent 2, EDSPD2, EG317677, Gm5077, r-gsp |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat C1s often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Trypsin-like serine protease
- Tryp_SPc
- peptidase
- serine protease domain
- linker domain
- protein binding
- complement subcomponent C
- identical protein binding
- EGF_CA
- CCP
- trypsin
- serine endopeptidase
- CUB
- Sushi repeat (SCR repeat)
- Coagulation Factor Xa inhibitory site
- SUSHI repeat
Pathways
Biological processes and signaling networks where the C1s gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- endometriosis
- COVID-19
- cholangiocarcinoma
- cholangiocarcinoma cancer
- Alzheimer disease
- preeclampsia
- epithelial cancer
- cold agglutinin disease
- coronary artery disease
- lung carcinoma
role in cell
- molecular cleavage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat C1s gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- complement activation, classical pathway
- innate immune response
- proteolysis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- blood microparticle
- extracellular region
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- calcium ion binding
- serine-type endopeptidase activity