Hoxb7 Gene Summary [Rat]
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including anterior/posterior pattern specification; positive regulation of branching involved in ureteric bud morphogenesis; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within embryonic skeletal system morphogenesis and myeloid cell differentiation. Predicted to be located in cytosol and nuclear body. Predicted to be active in nucleus. Orthologous to human HOXB7 (homeobox B7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hoxb7 |
| Official Name | homeo box B7 [Source:RGD Symbol;Acc:1559918] |
| Ensembl ID | ENSRNOG00000007611 |
| Bio databases IDs | |
| Aliases | homeo box B7 |
| Synonyms | HHO.C1, homeo box B7, HOMEOBOX C1, HOX2, Hox-2.3, HOX2C, Hox2r1b, R1b |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hoxb7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- hexapeptide domain
- nucleic acid binding
- protein binding
- glutamine-rich domain
- sequence-specific DNA binding
- acidic domain
- DNA binding
- YPWMK motif
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- colorectal cancer
- colon cancer
role in cell
- proliferation
- apoptosis
- quantity
- cell cycle progression
- phosphorylation in
- growth
- colony formation
- differentiation
- migration
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- nuclear bodies
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hoxb7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of branching involved in ureteric bud morphogenesis
- anterior/posterior pattern specification
- myeloid cell differentiation
- regulation of transcription, DNA-dependent
- embryonic organ development
- positive regulation of transcription from RNA polymerase II promoter
- embryonic skeletal system morphogenesis
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity