Nat10 Gene Summary [Rat]
Predicted to enable DNA polymerase binding activity; N-acetyltransferase activity; and tRNA binding activity. Predicted to be involved in several processes, including RNA modification; regulation of centrosome duplication; and regulation of macromolecule biosynthetic process. Predicted to be located in midbody. Predicted to be part of small-subunit processome and telomerase holoenzyme complex. Predicted to be active in nucleolus. Orthologous to human NAT10 (N-acetyltransferase 10). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nat10 |
| Official Name | N-acetyltransferase 10 [Source:RGD Symbol;Acc:1306717] |
| Ensembl ID | ENSRNOG00000008663 |
| Bio databases IDs | |
| Aliases | N-acetyltransferase 10 |
| Synonyms | AI429152, ALP, FLJ10774, hALP, Kre33, N-acetyltransferase 10, NET43, RGD1306717 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nat10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GNAT acetyltransferase 2
- tRNA(Met) cytidine acetyltransferase TmcA, N-terminal
- N-acetyltransferase
- Possible tRNA binding domain
- helicase
- enzyme binding
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- breast cancer
- neoplasia
- gastric adenocarcinoma
- metastasis
- pancreatic cancer
- esophageal cancer
- cervical cancer
- lung cancer
- renal clear cell adenocarcinoma
role in cell
- growth
- expression in
- production in
- proliferation
- phosphorylation in
- colony formation by
- damage in
- apoptosis
- quantity
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- pre-ribosome
- midbody
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nat10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translation
- rRNA modification
- positive regulation of translation
- regulation of centrosome duplication
- ribosomal small subunit biogenesis
- protein acetylation
- negative regulation of telomere maintenance via telomerase
- tRNA acetylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome, telomeric region
- small-subunit processome
- membrane
- midbody
- telomerase holoenzyme complex
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- DNA polymerase binding
- RNA binding
- protein binding
- tRNA N-acetyltransferase activity
- tRNA binding
- N-acetyltransferase activity