HOXB4 Gene Summary [Human]
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | HOXB4 |
| Official Name | homeobox B4 [Source:HGNC Symbol;Acc:HGNC:5115] |
| Ensembl ID | ENSG00000182742 |
| Bio databases IDs | |
| Aliases | homeobox B4 |
| Synonyms | B4, homeo box B4, HOX2, HOX-2.6, HOX2F, RGD1560113 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HOXB4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- double-stranded DNA binding
- sequence-specific DNA binding
- homeodomain
- DNA binding
- YPWMK motif
Pathways
Biological processes and signaling networks where the HOXB4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- herniation
- hypoplasia
- edema
- immune thrombocytopenia
- Crohn disease
- dyspnea
role in cell
- expression in
- proliferation
- cell death
- number
- differentiation
- self-renewal
- hematopoiesis
- quantity
- expansion
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- centrosome
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HOXB4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- anterior/posterior pattern specification
- hemopoietic stem cell differentiation
- spleen development
- morphogenesis of an epithelial sheet
- positive regulation of transcription from RNA polymerase II promoter
- bone marrow development
- embryonic skeletal system morphogenesis
- definitive hemopoiesis
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of stem cell differentiation
- somatic stem cell division
- hemopoietic stem cell proliferation
Cellular Component
Where in the cell the gene product is active
- centrosome
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity