Aldh1l2 Gene Summary [Rat]
Predicted to enable aldehyde dehydrogenase (NAD+) activity and formyltetrahydrofolate dehydrogenase activity. Predicted to be involved in 10-formyltetrahydrofolate catabolic process; NADPH regeneration; and folic acid metabolic process. Predicted to act upstream of or within with a positive effect on fatty acid beta-oxidation. Predicted to be located in mitochondrion and nucleoplasm. Orthologous to human ALDH1L2 (aldehyde dehydrogenase 1 family member L2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aldh1l2 |
| Official Name | aldehyde dehydrogenase 1 family, member L2 [Source:RGD Symbol;Acc:1309458] |
| Ensembl ID | ENSRNOG00000008586 |
| Bio databases IDs | |
| Aliases | aldehyde dehydrogenase 1 family, member L2 |
| Synonyms | aldehyde dehydrogenase 1 family member L2, aldehyde dehydrogenase 1 family, member L2, D330038I09Rik, mtFDH, RGD1309458 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Aldh1l2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Aldehyde dehydrogenase family
- betaine-aldehyde dehydrogenase
- Carboxy-terminal domain of Formyltransferase and similar domains
- methionyl-tRNA formyltransferase
- formyltetrahydrofolate dehydrogenase
- Formyl transferase, C-terminal domain
- Formyltransferase, catalytic core domain
- enzyme
- protein binding
- delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative
- delta-1-pyrroline-5-carboxylate dehydrogenase (PutA C-terminal domain)
- NAD(P)+-dependent aldehyde dehydrogenase superfamily
Pathways
Biological processes and signaling networks where the Aldh1l2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Aldh1l2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fatty acid beta-oxidation
- folic acid metabolic process
- 10-formyltetrahydrofolate catabolic process
- NADPH regeneration
- biosynthetic process
- one-carbon metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- mitochondrial matrix
- mitochondrion
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- aldehyde dehydrogenase (NAD) activity
- protein binding
- formyltetrahydrofolate dehydrogenase activity