Mal2 Gene Summary [Rat]
Predicted to be a structural constituent of myelin sheath. Predicted to be involved in myelination. Is active in glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; and synaptic vesicle membrane. Orthologous to human MAL2 (mal, T cell differentiation protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mal2 |
| Official Name | mal, T-cell differentiation protein 2 [Source:RGD Symbol;Acc:735066] |
| Ensembl ID | ENSRNOG00000008615 |
| Bio databases IDs | |
| Aliases | mal, T-cell differentiation protein 2 |
| Synonyms | AI461653, LOC100911027, mal, T-cell differentiation protein 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mal2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Membrane-associating domain
- protein binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- breast cancer
- Huntington disease
- organismal death
- hippocampal atrophy
role in cell
- expression in
- apoptosis
- phosphorylation in
- migration
- invasion by
- degradation in
- degradation
- sorafenib resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- raft fractions
- synaptic vesicle membrane
- glutaminergic synapse
- cellular membrane
- apical cell surfaces
- synapse
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mal2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- myelination
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- membrane raft
- membrane
- synaptic vesicle membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural constituent of myelin sheath