Cdc25a Gene Summary [Rat]
Enables phosphoprotein phosphatase activity. Involved in G1/S transition of mitotic cell cycle and positive regulation of cholangiocyte proliferation. Predicted to be active in cytoplasm and nucleus. Used to study autosomal recessive polycystic kidney disease. Biomarker of autosomal recessive polycystic kidney disease. Human ortholog(s) of this gene implicated in cervical cancer; prostate cancer; and urinary bladder cancer. Orthologous to human CDC25A (cell division cycle 25A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdc25a |
| Official Name | cell division cycle 25A [Source:RGD Symbol;Acc:621498] |
| Ensembl ID | ENSRNOG00000020737 |
| Bio databases IDs | |
| Aliases | cell division cycle 25A |
| Synonyms | CDC25A2, cell division cycle 25A, D9Ertd393e |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cdc25a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- protein-tyrosine-phoshatase
- cyclin B1-CDK1 binding domain
- catalytic domain
- Rhodanese Homology Domain
- protein binding
- Rhodanese-like domain
- phosphatase domain
- RHOD
- KEN box
- M-phase inducer phosphatase
- protein phosphatase
- phosphatase
- chaperone binding
- MAP kinase site
Pathways
Biological processes and signaling networks where the Cdc25a gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- atopic dermatitis
- organismal death
- polycythemia vera
- autosomal dominant polycystic liver disease
- essential thrombocythemia
- cervical cancer
- diabetic nephropathy
- lung adenocarcinoma
- lung adenocarcinoma formation
role in cell
- expression in
- activation in
- replication in
- phosphorylation in
- cell death
- damage in
- survival
- apoptosis
- binding in
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- nuclear envelope
- neurites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cdc25a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- cell division
- G2/M transition of mitotic cell cycle
- G1/S transition of mitotic cell cycle
- response to radiation
- cellular response to UV
- positive regulation of DNA replication
- positive regulation of G2/M transition of mitotic cell cycle
- regulation of cyclin-dependent protein kinase activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- phosphoprotein phosphatase activity
- protein kinase binding
- protein binding
- protein tyrosine phosphatase activity
- chaperone binding