Ext2 Gene Summary [Rat]
Predicted to enable UDP-glycosyltransferase activity and protein dimerization activity. Predicted to be involved in glycosaminoglycan biosynthetic process; ossification; and polysaccharide biosynthetic process. Predicted to act upstream of or within with a positive effect on gene expression; protein N-linked glycosylation; and sulfation. Predicted to act upstream of or within several processes, including multicellular organismal-level water homeostasis; proteoglycan biosynthetic process; and skeletal system development. Predicted to be located in endoplasmic reticulum. Predicted to be part of UDP-N-acetylglucosamine transferase complex. Predicted to be active in Golgi apparatus. Orthologous to human EXT2 (exostosin glycosyltransferase 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ext2 |
| Official Name | exostosin glycosyltransferase 2 [Source:RGD Symbol;Acc:1307707] |
| Ensembl ID | ENSRNOG00000008944 |
| Bio databases IDs | |
| Aliases | exostosin glycosyltransferase 2 |
| Synonyms | Exostoses (Multiple) 2, exostosin glycosyltransferase 2, SOTV, SSMS |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ext2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Exostosin family
- glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase
- Glycosyl transferase family 64 domain
- acetylglucosaminyltransferase
- enzyme
- protein binding
- glucuronosyl-N-acetylglucosaminyl-proteoglycan
- glycosyltransferase
- glucuronosyltransferase
- N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase
- ribitol-5-phosphate xylosyltransferase 1, and related proteins
- protein homodimerization
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Ext2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin resistance
- liver cancer
- liver neoplasia
- digestive system cancer
- abdominal cancer
- cancer
- multiple exostoses type II
- hereditary cancer-predisposing syndrome
- seizures, scoliosis, and macrocephaly syndrome
- EXT2-related syndrome
role in cell
- expression in
- differentiation
- binding
- ossification by
- N-glycosylation in
- disorganization
- sulfation in
- 6-O-sulfation in
- dysfunction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ext2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
- heart contraction
- heparan sulfate proteoglycan biosynthetic process
- endochondral bone morphogenesis
- sodium ion homeostasis
- chondrocyte differentiation
- fluid transport
- cellular response to fibroblast growth factor stimulus
- glycosaminoglycan biosynthetic process
- protein N-linked glycosylation
- vasodilation
- regulation of blood pressure
- ossification
- multicellular organismal water homeostasis
- polysaccharide biosynthetic process
- gene expression
- sulfation
- heparin biosynthetic process
- mesoderm formation
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane
- UDP-N-acetylglucosamine transferase complex
- Golgi membrane
- endoplasmic reticulum
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- heparan sulfate N-acetylglucosaminyltransferase activity
- transferase activity, transferring glycosyl groups
- protein binding
- protein homodimerization activity
- acetylglucosaminyltransferase activity
- metal ion binding
- protein heterodimerization activity
- glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
- N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity
- glucuronosyltransferase activity