Ndst1 Gene Summary [Rat]
Enables heparan sulfate N-deacetylase activity and heparan sulfate N-sulfotransferase activity. Involved in heparan sulfate proteoglycan biosynthetic process. Predicted to be located in trans-Golgi network membrane. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 46. Orthologous to human NDST1 (N-deacetylase and N-sulfotransferase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ndst1 |
| Official Name | N-deacetylase and N-sulfotransferase 1 [Source:RGD Symbol;Acc:69303] |
| Ensembl ID | ENSRNOG00000019014 |
| Bio databases IDs | |
| Aliases | N-deacetylase and N-sulfotransferase 1 |
| Synonyms | 1200015G06RIK, b2b2230Clo, HSNST, HSNST 1, HSST, HSST1, MRT46, N-deacetylase and N-sulfotransferase 1, N-deacetylase and N-sulphotransferase 1, N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1, N-deacetylase/N-sulphotransferase (heparan glucosaminyl) 1, N-HSST, N-HSST 1, NST1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ndst1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- carboxylic ester hydrolase
- sulfotransferase
- [heparan sulfate]-glucosamine N-sulfotransferase
- N-acetylglucosamine deacetylase
- Sulfotransferase domain
- enzyme
- protein binding
- deacetylase
- Sulfotransferase family
- heparan sulfate-N-deacetylase
Pathways
Biological processes and signaling networks where the Ndst1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- microphthalmia
- autosomal recessive mental retardation type 46
- congenital heart disease
- aphakia
- airway hyperresponsiveness
- atelectasis
- hypoplasia
- global developmental delay
role in cell
- migration
- expression in
- apoptosis
- cellular infiltration by
- proliferation
- phosphorylation in
- binding
- recruitment
- abnormal morphology
- sprouting
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- Golgi membrane
- trans Golgi network
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ndst1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- heparan sulfate proteoglycan biosynthetic process, enzymatic modification
- heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
- coronary vasculature development
- embryonic neurocranium morphogenesis
- fibroblast growth factor receptor signaling pathway
- respiratory gaseous exchange
- positive regulation of MAPK cascade
- cardiac septum development
- embryonic viscerocranium morphogenesis
- midbrain development
- inflammatory response
- forebrain development
- aorta development
- positive regulation of smoothened signaling pathway
- heparin biosynthetic process
Cellular Component
Where in the cell the gene product is active
- Golgi membrane
- Golgi apparatus
- trans-Golgi network membrane
Molecular Function
What the gene product does at the molecular level
- [heparan sulfate]-glucosamine N-sulfotransferase activity
- protein binding
- N-acetylglucosamine deacetylase activity
- deacetylase activity