Ttll5 Gene Summary [Rat]
Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in sperm axoneme assembly. Predicted to act upstream of or within several processes, including flagellated sperm motility; protein polyglutamylation; and retina development in camera-type eye. Predicted to be located in several cellular components, including 9+0 non-motile cilium; centrosome; and cytosol. Predicted to be active in ciliary basal body. Human ortholog(s) of this gene implicated in cone-rod dystrophy 19. Orthologous to human TTLL5 (tubulin tyrosine ligase like 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ttll5 |
| Official Name | tubulin tyrosine ligase like 5 [Source:RGD Symbol;Acc:1563583] |
| Ensembl ID | ENSRNOG00000009318 |
| Bio databases IDs | |
| Aliases | tubulin tyrosine ligase like 5 |
| Synonyms | 1700048H13Rik, 2310009M18Rik, 4930556H18Rik, CORD19, D630041K24Rik, KIAA0998, mKIAA0998, RGD1563583, STAMP, Tubulin ligase, tubulin tyrosine ligase like 5, tubulin tyrosine ligase-like family, member 5 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ttll5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- acid-D-amino acid ligase
- Carbamoyl-phosphate synthase L chain, ATP binding domain
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- open-angle glaucoma
- cone-rod dystrophy type 19
- retinitis pigmentosa
- acute myeloid leukemia
- retinal dystrophy
- carpal tunnel syndrome
- cone-rod dystrophy
- purkinje cell degeneration
- central areolar choroidal sclerosis
role in cell
- degeneration
- motility
- polyglutamylation in
- glutamylation in
- disruption in
- disruption
- fertilization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- non-motile cilium
- cilia
- Plasma Membrane
- basal bodies
- centrosome
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ttll5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- protein polyglutamylation
- retina development in camera-type eye
- microtubule cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cilium
- cytosol
- plasma membrane
- microtubule
Molecular Function
What the gene product does at the molecular level
- tubulin binding
- ATP binding
- metal ion binding
- tubulin-glutamic acid ligase activity