TTLL5 Gene Summary [Human]
This gene encodes a member of the tubulin tyrosine ligase like protein family. This protein interacts with two glucocorticoid receptor coactivators, transcriptional intermediary factor 2 and steroid receptor coactivator 1. This protein may function as a coregulator of glucocorticoid receptor mediated gene induction and repression. This protein may also function as an alpha tubulin polyglutamylase.[provided by RefSeq, Feb 2010]
Details
| Type | Processed Transcript |
| Official Symbol | TTLL5 |
| Official Name | tubulin tyrosine ligase like 5 [Source:HGNC Symbol;Acc:HGNC:19963] |
| Ensembl ID | ENSG00000119685 |
| Bio databases IDs | |
| Aliases | tubulin tyrosine ligase like 5, tubulin polyglutamylase TTLL5, SRC1 and TIF2-associated modulatory protein |
| Synonyms | 1700048H13Rik, 2310009M18Rik, 4930556H18Rik, CORD19, D630041K24Rik, KIAA0998, mKIAA0998, RGD1563583, STAMP, Tubulin ligase, tubulin tyrosine ligase like 5, tubulin tyrosine ligase-like family, member 5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TTLL5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- acid-D-amino acid ligase
- Carbamoyl-phosphate synthase L chain, ATP binding domain
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- open-angle glaucoma
- cone-rod dystrophy type 19
- retinitis pigmentosa
- acute myeloid leukemia
- retinal dystrophy
- carpal tunnel syndrome
- cone-rod dystrophy
- purkinje cell degeneration
- central areolar choroidal sclerosis
role in cell
- degeneration
- motility
- polyglutamylation in
- glutamylation in
- disruption in
- disruption
- fertilization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- non-motile cilium
- cilia
- Plasma Membrane
- basal bodies
- centrosome
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TTLL5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- protein polyglutamylation
- retina development in camera-type eye
- microtubule cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cilium
- cytosol
- plasma membrane
- microtubule
Molecular Function
What the gene product does at the molecular level
- tubulin binding
- ATP binding
- metal ion binding
- tubulin-glutamic acid ligase activity