Pnp Gene Summary [Rat]
Enables purine-nucleoside phosphorylase activity. Predicted to be involved in several processes, including allantoin metabolic process; nucleobase-containing small molecule metabolic process; and positive regulation of interleukin-2 production. Predicted to act upstream of or within inosine catabolic process; positive regulation of T cell activation; and urate biosynthetic process. Located in extracellular region. Human ortholog(s) of this gene implicated in purine nucleoside phosphorylase deficiency and purine-pyrimidine metabolic disorder. Orthologous to human PNP (purine nucleoside phosphorylase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pnp |
| Official Name | purine nucleoside phosphorylase [Source:RGD Symbol;Acc:1597189] |
| Ensembl ID | ENSRNOG00000009982 |
| Bio databases IDs | |
| Aliases | purine nucleoside phosphorylase |
| Synonyms | Nicotinamide Nucleoside Phosphorylase, NP, Np-1, Np-2, NUCLEOSIDE PHOSPHORYLASE, Pnp1, PNPH, PRO1837, PUNP, purine-nucleoside phosphorylase, PURINE PHOSPHORYLASE |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pnp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- purine-nucleoside phosphorylase
- nucleoside phosphorylase-I family
- enzyme
- protein binding
- phosphate binding
- identical protein binding
- guanosine phosphorylase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- purine nucleoside phosphorylase deficiency
- peripheral T-cell lymphoma
- pervasive developmental disorder
- renal cell carcinoma
- renal cell cancer
- severe combined immunodeficiency
- relapsed peripheral T-cell lymphoma
- HER2 negative hormone receptor negative breast cancer
role in cell
- expression in
- quantity
- proliferation
- apoptosis
- number
- response
- cytotoxicity
- differentiation
- morphology
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pnp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nucleotide biosynthetic process
- purine-containing compound salvage
- deoxyadenosine catabolic process
- dAMP catabolic process
- purine ribonucleoside salvage
- positive regulation of T cell proliferation
- response to xenobiotic stimulus
- deoxyinosine catabolic process
- IMP catabolic process
- positive regulation of alpha-beta T cell differentiation
- nucleobase-containing compound metabolic process
- allantoin metabolic process
- inosine catabolic process
- immune response
- urate biosynthetic process
- nicotinamide riboside catabolic process
- positive regulation of interleukin-2 production
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
- secretory granule lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- purine base binding
- guanosine phosphorylase activity
- phosphate ion binding
- purine-nucleoside phosphorylase activity
- nucleoside binding