AC126641.1 Gene Summary [Rat]
Predicted to enable transmembrane transporter activity. Predicted to be involved in regulation of presynaptic cytosolic calcium ion concentration and regulation of synaptic vesicle exocytosis. Located in synaptic vesicle. Is active in glutamatergic synapse and synaptic vesicle membrane. Orthologous to human SV2B (synaptic vesicle glycoprotein 2B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | AC126641.1 |
| Official Name | synaptic vesicle glycoprotein 2b [Source:NCBI gene;Acc:117556] |
| Ensembl ID | ENSRNOG00000011160 |
| Bio databases IDs | |
| Aliases | synaptic vesicle glycoprotein 2b |
| Synonyms | A830038F04Rik, HsT19680, KIAA0735, LOC100128403, mKIAA0735, SLC22B2, synaptic vesicle glycoprotein 2B |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ac126641.1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- benzoate transport
- Major Facilitator Superfamily
- protein binding
- Pentapeptide repeats (9 copies)
- synaptic vesicle protein SV2
- cation transport protein
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- non-insulin-dependent diabetes mellitus
- seizures
- growth failure
- age-related hearing loss
- myopia
- gout
regulates
- SYT1
- neurotransmitter
role in cell
- proliferation
- expression in
- exocytosis
- function
- synaptic transmission
- electrophysiology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- synaptic vesicle membrane
- glutaminergic synapse
- cellular membrane
- synaptic vesicles
- growth cone
- clathrin-coated vesicles
- synaptic vesicle fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ac126641.1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neurotransmitter transport
- transmembrane transport
- regulation of synaptic vesicle exocytosis
- synaptic transmission
Cellular Component
Where in the cell the gene product is active
- synaptic vesicle
- acrosomal vesicle
- membrane
- synaptic vesicle membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- transmembrane transporter activity