NEWGENE_621351 Gene Summary [Rat]
Predicted to enable several functions, including identical protein binding activity; platelet-derived growth factor binding activity; and protease binding activity. Predicted to be an extracellular matrix structural constituent conferring tensile strength. Involved in several processes, including cellular response to retinoic acid; cellular response to thyroid hormone stimulus; and response to norepinephrine. Predicted to be located in extracellular region. Predicted to be part of collagen type I trimer. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Biomarker of hypothyroidism; muscular atrophy; pulmonary fibrosis; and ureteral obstruction. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome (multiple); heart valve disease; intracranial aneurysm; osteogenesis imperfecta (multiple); and osteoporosis. Orthologous to human COL1A2 (collagen type I alpha 2 chain). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | NEWGENE_621351 |
| Official Name | collagen, type I, alpha 2 [Source:RGD Symbol;Acc:9452897] |
| Ensembl ID | ENSRNOG00000011292 |
| Bio databases IDs | |
| Aliases | collagen, type I, alpha 2 |
| Synonyms | alpha2(I) COLLAGEN, alpha 2(I) COLLAGEN precursor, alpha2(I) PROCOLLAGEN, circCOL1A2, Col1 alpha 2, Col1 α 2, Cola-2, COLLAGEN 1 alpha2, COLLAGEN alpha 2(I), COLLAGEN alpha 2(I) CHAIN precursor, COLLAGEN alpha2 type1, COLLAGEN I, COLLAGEN I alpha2, COLLAGEN type1 alpha2, COLLAGEN type I alpha2, collagen, type I, alpha 2, collagen type I alpha 2 chain, COLLAGEN type I PRO alpha 2, COLLAGEN type I PRO α 2, collagen, type I, α 2, collagen type I α 2 chain, COLLAGEN α 2(I), COLLAGEN α 2(I) CHAIN precursor, EDSARTH2, EDSCV, LOC100911218, NEWGENE 621351, OI4, oim, Pro-alpha2(i)collagen, PROCOLLAGEN alpha2(I), Procollagen type1 alpha2 chain, Procollagen type 1, prepro-alpha2 chain, α 2(I) COLLAGEN precursor |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Newgene_621351 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SMAD binding
- triple helical domain
- Fibrillar collagen C-terminal domain
- C-propeptide domain
- protease binding
- protein binding activity, bridging
- Collagen triple helix repeat (20 copies)
- protein binding
- C-terminal telopeptide domain
- identical protein binding
- growth factor binding
- 8-9 Fibronectin conserved module type I binding sequence
Pathways
Biological processes and signaling networks where the Newgene_621351 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- hepatic fibrosis
- osteogenesis imperfecta type III
- organismal death
- osteogenesis imperfecta type IVB
- osteogenesis imperfecta type I
- Dupuytren contracture
- osteogenesis imperfecta
- diabetic nephropathy
- osteoporosis
role in cell
- growth
- expression in
- proliferation
- dilation
- assembly
- organization
- number
- pyroptosis
- production in
- structural integrity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- endoplasmic reticulum lumen
- extracellular matrix
- cellular protrusions
- cell membrane leading edge
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Newgene_621351 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- bone mineralization
- transforming growth factor beta receptor signaling pathway
- extracellular matrix assembly
- odontogenesis
- Rho protein signal transduction
- skin morphogenesis
- regulation of blood pressure
- cellular response to amino acid stimulus
- skeletal system development
- blood vessel development
- extracellular matrix organization
- collagen fibril organization
- protein heterotrimerization
- collagen metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- extracellular vesicular exosome
- collagen type I
- extracellular region
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- SMAD binding
- metal ion binding
- extracellular matrix structural constituent conferring tensile strength
- protease binding
- extracellular matrix structural constituent
- protein binding, bridging
- platelet-derived growth factor binding