Nthl1 Gene Summary [Rat]
Predicted to enable DNA binding activity and catalytic activity, acting on DNA. Predicted to be involved in base-excision repair, AP site formation and nucleotide-excision repair. Predicted to be located in mitochondrion. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in familial adenomatous polyposis 3. Orthologous to human NTHL1 (nth like DNA glycosylase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nthl1 |
| Official Name | nth-like DNA glycosylase 1 [Source:RGD Symbol;Acc:1309289] |
| Ensembl ID | ENSRNOG00000012213 |
| Bio databases IDs | |
| Aliases | nth-like DNA glycosylase 1 |
| Synonyms | FAP3, hNTH1, NTH1, nth (endonuclease III)-like 1 (E.coli), nth-like DNA glycosylase 1, OCTS3, T4N5 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nthl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DNA N-glycosylase
- FES
- DNA-(apurinic or apyrimidinic site) lyase
- enzyme
- protein binding
- endonuclease III
- Helix-hairpin-helix motif
- carbon-oxygen lyase
- HhH-GPD superfamily base excision DNA repair protein
- ENDO3c
- endonuclease
- damaged DNA binding
- pyrimidine-specific oxidized base lesion DNA N-glycosylase
- double-stranded DNA binding
- DNA-formamidopyrimidine glycosylase
Pathways
Biological processes and signaling networks where the Nthl1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- hereditary cancer-predisposing syndrome
- familial adenomatous polyposis type 3
- mucoepidermoid carcinoma
- colorectal cancer
- NTHL1-deficiency tumor predisposition syndrome
- adenomatous polyposis
- colon adenoma formation
- colon adenomatous polyp
- colonic polyposis
role in cell
- accumulation in
- growth
- accumulation
- replication in
- formation
- formation in
- DNA damage response
- cell focus formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Mitochondria
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nthl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- base-excision repair, AP site formation
- nucleotide-excision repair
- depyrimidination
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrion
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- endonuclease activity
- oxidized pyrimidine base lesion DNA N-glycosylase activity
- double-stranded DNA binding
- DNA-(apurinic or apyrimidinic site) lyase activity
- DNA N-glycosylase activity
- 4 iron, 4 sulfur cluster binding
- damaged DNA binding
- oxidized purine base lesion DNA N-glycosylase activity