Cdh16 Gene Summary [Rat]
Predicted to enable calcium ion binding activity. Predicted to be involved in cell adhesion. Predicted to act upstream of or within calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules. Predicted to be located in basolateral plasma membrane. Predicted to be active in plasma membrane. Orthologous to human CDH16 (cadherin 16). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdh16 |
| Official Name | cadherin 16 [Source:RGD Symbol;Acc:1311638] |
| Ensembl ID | ENSRNOG00000012222 |
| Bio databases IDs | |
| Aliases | cadherin 16 |
| Synonyms | cadherin 16, KSP-cadherin |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cdh16 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cadherin repeat-like domain
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Cdh16 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- thyroid carcinoma
- epithelial thyroid cancer
- renal cell carcinoma
- renal cell cancer
- Wilms tumor
- Wilms tumorigenesis
- renal failure
- anaplastic thyroid carcinoma
- anaplastic thyroid cancer
role in cell
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- basolateral membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cdh16 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcium-dependent cell-cell adhesion
- cell adhesion
- homophilic cell adhesion
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- basolateral plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding