Arhgef10 Gene Summary [Rat]
Predicted to enable guanyl-nucleotide exchange factor activity and kinesin binding activity. Predicted to be involved in several processes, including activation of GTPase activity; cytoskeleton organization; and positive regulation of stress fiber assembly. Predicted to be active in centrosome and cytoplasm. Human ortholog(s) of this gene implicated in alcohol-related birth defects. Orthologous to human ARHGEF10 (Rho guanine nucleotide exchange factor 10). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arhgef10 |
| Official Name | Rho guanine nucleotide exchange factor 10 [Source:RGD Symbol;Acc:1565043] |
| Ensembl ID | ENSRNOG00000012561 |
| Bio databases IDs | |
| Aliases | Rho guanine nucleotide exchange factor 10 |
| Synonyms | 6430549H08RIK, GEF10, mKIAA0294, RGD1565043, Rho guanine nucleotide exchange factor 10, SNCV |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Arhgef10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGEF
- guanyl-nucleotide exchange factor
- WD40 repeated domain
- PH domain
- enzyme
- protein binding
- kinesin binding
- RhoGEF domain
Pathways
Biological processes and signaling networks where the Arhgef10 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- Charcot-Marie-Tooth disease
- obesity
- multiple sclerosis
- slowed nerve conduction velocity, autosomal dominant
- dementia
- preeclampsia
- disorder of pregnancy
- chemotherapy-induced peripheral neuropathy
regulates
- RHOB
- 5-hydroxytryptamine
- dopamine
role in cell
- proliferation
- apoptosis
- activation in
- disruption
- assembly
- disruption in
- duplication
- barrier integrity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- centrosome
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Arhgef10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- myelination in peripheral nervous system
- regulation of small GTPase mediated signal transduction
- positive regulation of stress fiber assembly
- centrosome duplication
- actin cytoskeleton organization
- spindle assembly involved in mitosis
Cellular Component
Where in the cell the gene product is active
- centrosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity
- kinesin binding