Mmp15 Gene Summary [Rat]
Predicted to enable metalloendopeptidase activity. Involved in response to estradiol. Predicted to be located in extracellular matrix and membrane. Predicted to be active in extracellular space. Orthologous to human MMP15 (matrix metallopeptidase 15). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mmp15 |
| Official Name | matrix metallopeptidase 15 [Source:RGD Symbol;Acc:1308937] |
| Ensembl ID | ENSRNOG00000012622 |
| Bio databases IDs | |
| Aliases | matrix metallopeptidase 15 |
| Synonyms | matrix metallopeptidase 15, MT2-MMP, MT-MMP 2, SMCP-2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mmp15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Hemopexin-like repeats
- Matrixin
- metalloexopeptidase
- hemopexin domain
- catalytic domain
- peptidase
- HX
- Zinc-dependent metalloprotease
- protein binding
- enzyme activator activity
- Putative peptidoglycan binding domain
- ZnMc
- zinc ion binding
- aminopeptidase
- metalloendopeptidase
Pathways
Biological processes and signaling networks where the Mmp15 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Agranulocyte Adhesion and Diapedesis
- Axonal Guidance Signaling
- Bladder Cancer Signaling
- Colorectal Cancer Metastasis Signaling
- Estrogen Receptor Signaling
- Granulocyte Adhesion and Diapedesis
- HIF1α Signaling
- Inhibition of Matrix Metalloproteases
- Leukocyte Extravasation Signaling
- Molecular Mechanisms of Cancer
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- growth failure
- breast cancer
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- Dupuytren contracture
- developmental disorder
- lung cancer
- osteoarthritis
- microscopic hematuria
role in cell
- phosphorylation in
- growth
- adhesion
- disassembly
- invasion by
- angiogenesis by
- degradation by
- intravasation by
- degradation
- invasion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- invadopodia
- cell surface
- cellular membrane
- Plasma Membrane
- endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mmp15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- extracellular matrix disassembly
- proteolysis
- extracellular matrix organization
- response to estradiol stimulus
- endodermal cell differentiation
- collagen catabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular matrix
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- metalloaminopeptidase activity
- enzyme activator activity
- metalloendopeptidase activity