Adamts6 Gene Summary [Rat]
Predicted to enable metalloendopeptidase activity. Predicted to be involved in extracellular matrix organization and proteolysis. Predicted to act upstream of or within circulatory system development and kidney development. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Orthologous to human ADAMTS6 (ADAM metallopeptidase with thrombospondin type 1 motif 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adamts6 |
| Official Name | ADAM metallopeptidase with thrombospondin type 1 motif, 6 [Source:RGD Symbol;Acc:1307678] |
| Ensembl ID | ENSRNOG00000012655 |
| Bio databases IDs | |
| Aliases | ADAM metallopeptidase with thrombospondin type 1 motif, 6 |
| Synonyms | A930019D11Rik, ADAM metallopeptidase with thrombospondin type 1 motif 6, ADAM metallopeptidase with thrombospondin type 1 motif, 6, b2b1879.1Clo, b2b2029Clo, b2b2182Clo, b2b2187.1Clo, b2b2228Clo, LOC345667 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Adamts6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thrombospondin type 1 repeats
- Thrombospondin type 1 domain
- Reprolysin family propeptide
- ADAMTS cysteine-rich domain 2
- ADAMTS cysteine-rich domain
- peptidase
- PLAC (protease and lacunin) domain
- metallopeptidase
- ADAM-TS Spacer 1
- ZnMc
- Metallo-peptidase family M12B Reprolysin-like
- Reprolysin (M12B) family zinc metalloprotease
- Spondin-like TSP1 domain
Pathways
Biological processes and signaling networks where the Adamts6 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- COVID-19
- atopic dermatitis
- osteosarcoma
- major depression
- mood disorder
- osteoarthritis
- open-angle glaucoma
- glioblastoma
- glioblastoma cancer
regulates
role in cell
- apoptosis
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Adamts6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- aorta development
- kidney development
- proteolysis
- coronary vasculature development
- extracellular matrix organization
- cardiac septum development
Cellular Component
Where in the cell the gene product is active
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- metalloendopeptidase activity
- metallopeptidase activity