Adamts6 Gene Summary [Mouse]
Predicted to enable metalloendopeptidase activity. Acts upstream of or within circulatory system development and kidney development. Predicted to be active in extracellular matrix. Is expressed in embryo and future forebrain. Orthologous to human ADAMTS6 (ADAM metallopeptidase with thrombospondin type 1 motif 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Adamts6 |
| Official Name | a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6 [Source:MGI Symbol;Acc:MGI:1347348] |
| Ensembl ID | ENSMUSG00000046169 |
| Bio databases IDs | |
| Aliases | a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6 |
| Synonyms | A930019D11Rik, ADAM metallopeptidase with thrombospondin type 1 motif 6, ADAM metallopeptidase with thrombospondin type 1 motif, 6, b2b1879.1Clo, b2b2029Clo, b2b2182Clo, b2b2187.1Clo, b2b2228Clo, LOC345667 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Adamts6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thrombospondin type 1 repeats
- Thrombospondin type 1 domain
- Reprolysin family propeptide
- ADAMTS cysteine-rich domain 2
- ADAMTS cysteine-rich domain
- peptidase
- PLAC (protease and lacunin) domain
- metallopeptidase
- ADAM-TS Spacer 1
- ZnMc
- Metallo-peptidase family M12B Reprolysin-like
- Reprolysin (M12B) family zinc metalloprotease
- Spondin-like TSP1 domain
Pathways
Biological processes and signaling networks where the Adamts6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- COVID-19
- atopic dermatitis
- osteosarcoma
- major depression
- mood disorder
- osteoarthritis
- open-angle glaucoma
- glioblastoma
- glioblastoma cancer
regulates
role in cell
- apoptosis
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Adamts6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- aorta development
- kidney development
- proteolysis
- coronary vasculature development
- extracellular matrix organization
- cardiac septum development
Cellular Component
Where in the cell the gene product is active
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- metalloendopeptidase activity
- metallopeptidase activity